Nmda Antagonists as Potential Analgesic Drugs

ISBN-13: 9783764360115 / Angielski / Twarda / 2002 / 194 str.

D. J. S. Sirinathsinghji; Ray G. Hill; Dalip J. S. Sirinathsinghji

Opis

This book compiles the most recent information on molecular biology, physiology, and pharmacology of NMDA receptors, their neuroanatomical localization within specific neural pathways involved in nociception, and experimental and clinical evidence demonstrating the potential of receptor antagonists of NMDA and other excitatory amino acids in the treatment of pain states.

Spis treści

Pharmacology and electrophysiology of excitatory amino acid receptors.- Distribution of NMDA receptors in brain and spinal cord.- Spinal nociceptive processing: NMDA receptors and modulation by neuropeptides.- The NMDA receptor, pain and central sensitization.- Some pharmacological aspects of NMDA-mediated nociceptive transmission in the rat spinal cord as revealed by c-fos immunocytochemistry.- Interaction of NMDA and other neurotransmitter receptor systems in modulation of nociception.- Behavioural studies on the potential of NMDA receptor antagonists as analgesics.- Clinically available glutamate receptor antagonists in neuropathic pain states.- Future prospects for improved analgesic therapy.