Section 1: General properties of NO/metabolites in human diseasesSection 2: Development of novel NO donors/inhibitors and NO complexes: properties, cell signaling, synergy Section 3: Pharmacokinetics of NO donors/inhibitors in animal models and toxicities Section 4: Red-Ox signaling and modification of proteins. Characterization of their modified functions Section 5: Therapeutic applications of NO donors/inhibitors in non-cancer related human diseases Section 6: Therapeutic applications of NO donors/inhibitors in various cancersConcluding remarks and future perspectives