Nitric Oxide and Inflammation

ISBN-13: 9783034894883 / Angielski / Miękka / 2012 / 280 str.

Daniela Salvemini;Timothy R. Billiar;Yoram Vodovotz

Opis

Literally thousands of papers have been published on nitric oxide over the past ten years. But there is no single monograph available that has previously attempted to summarize the important features of the roles of nitric oxide in inflammation. The voluminous literature regarding the incredible range of chemical and biological effects of nitric oxide and reactive nitrogen oxide species, RNOS, may present a tangle of confusing information to the researcher. This volume brings together experts from nitric oxide and inflammation research and presents a concise up-to-date overview as well as future aspects of this rapidly growing field.

Spis treści

Regulation of the inducible nitric oxide synthase (iNOS) gene.- Superoxide anion release from inducible nitric oxide synthase.- Direct and indirect modulation of the inducible nitric oxide synthase by nitric oxide: feedback mechanisms in inflammation.- Nitric oxide regulation of eicosanoid production.- Local and systemic inflammation: role of poly (ADP-ribose) synthetase activation by reactive nitrogen species.- Nitric oxide regulation of leukocyte adhesion molecule expression.- Nitric oxide and leukocyte recruitment.- Nitric oxide regulation of lymphocyte function.- Role of nitric oxide and reactive oxygen species in arthritis.- Role of nitric oxide in chronic gut inflammation.- Nitric oxide and inflammatory disorders of the skin.- Roles of nitric oxide, superoxide, and peroxynitrite in myocardial ischemia-reperfusion injury and ischemic preconditioning.- Nitric oxide and myocarditis.- Nitric oxide in shock: sepsis and hemorrhage.- Nitric oxide as a mediator of interleukin-2 induced cardiovascular toxicity and antitumor activity.