Nitric Oxide and Cancer: Pathogenesis and Therapy

ISBN-13: 9783319136103 / Angielski / Twarda / 2015 / 308 str.

Benjamin Bonavida

Opis

Advances in Nitric Oxide and Cancer is a volume that serves to give the latest research on nitric oxide (NO) and cancer. More specifically, the volume reviews significant advances in the application of NO-mediated drugs. The volume explores nitric oxide and its relationship to cancer spanning from its roles in the pathogenesis, prognosis, gene and protein modifications, regulation of resistance to cytotoxics, and therapeutic applications. With chapters written by leading experts, the volume addresses the burgeoning interest in a rapidly advancing field and provides a valuable resource to scientists who have initiated research as well as clinical investigations in their laboratories on the various roles of NO and cancer.

Recenzje

"It describes the current perceptions on the role of NO^. in cancer and a possible therapeutic application of NO^. in the clinical practice. ... The book also presents several mechanisms of multiple effects and potential of NO^. for therapeutic use under optimal conditions. It can be recommended to all readers who are interested in the pathogenesis and therapy of cancer." (Darina Slamenova, Neoplasma, Vol. 62 (6), 2015)

Spis treści

Part I: Molecular Cell Signaling by NO in cancer
1. Inflammation-associated Carcinogenesis Involved Interaction Between with iNOS/NO and WNT/beta-catenin
Qiang Du and David A. Geller

2. NO and Genomic Stability
Vasily A. Yakovlev

3. Targeting Hyponitroxia in Cancer Therapy
Bryan Oronsky, Neil Oronsky, Michelle Lybeck, Gary Fanger, Jan Scicinski

4. Mechanism of NO-dependent Regulation of Invasion and Metastasis
Aideen E Ryan, Amy J Burke, Francis J Giles, Francis J Sullivan, Sharon A Glynn

5. NO Role in Protumorigenesis and Hypoxia
Lynne-Marie Postovit

Part II: S-nitrosylation and cancer
6. Impacts of S-nitrosylation in Cancer
Tysha N. Medeiros, Dana M. Jarigese, Melissa A. Edwards and
Mark A. Brown

7. S-nitrosylation of Cancer Cells
Ali Bettaieb, Stéphanie Plenchette, Catherine Paul, Véronique Laurens, Sabrina Romagny, Jean-François Jeannin

8. Role of S-nitrosylation in Cancer Metastasis
Sudjit Luanpitpong and Yon Rojanasakul

Part III: Modulation of anti-tumor immune responses by NO
9. NO Immunity and Cancer
Hermes J. Garbán

10. Regulation of Anti-tumor Responses by NO
Peter Siesjö

11. NO Immune Modulation and Tumor Growth
Naveena B. Janakiram and Chinthalapally V. Rao

Part IV: Therapeutics and overcoming resistance
12. Role of NO in Chemo-immune Resistance
Benjamin Bonavida

13. Emerging Role of NO-mediated Therapeutics
Cian M. McCrudden and Helen O. McCarthy
14. PDT and NO
Emilia Della Pietra and Valentina Rapozzi

15. Regulation of Cell Death by NO
Jordi Muntané, Francisco Gallardo-Chamizo, Sheila Pereira, Ángela M. De los Santos, Ángeles Rodríguez-Hernández, Luís M. Marín, Jose M. Álamo, Francisco J Padillo

16. Discovery and Development of RRx-001
Jan Scicinski, Bryan Oronsky, Shoucheng Ning, Gary R Fanger, Susan J Knox, Mark Bednarski

Part V: NO Meditated Alterations in Gene Products
17. Nitric Oxide Coagulation and Cancer
Benjamin A. Derman, Hau C. Kwaan, Malak Elbatarny, Maha Othman
 
18. Neutrosphyngomyelinase 2
Bei Lei Sun and Bulent Mutus

O autorze

Dr. Benjamin Bonavida is a professor at UCLA's David Geffen School of Medicine for the Department of Microbiology, Immunology, & Molecular Genetics. His other appointments include being a member of the Department of Defense Congressionally Directed Medical Research Program, Member of the National Cancer Institute's SPORE Program, member of the International Scientific Advisory Board of the Israel Cancer Research Foundation, to name a few. He's currently a scientific reviewer for several journals and a member of editorial boards including Journal of Clinical Immunology, International Journal of Oncology, and Cancer Biotherapy & Radiopharmaceuticals.

Blurb

Nitric Oxide and Cancer: Pathogenesis and Therapy provides the latest research and applications of nitric oxide (NO) in cancer written by experts in the field. The volume reviews significant advances in the biochemical and molecular biology of NO-mediated effects in cancer. Additionally, it explores NO and its relationship to cancer, delineating its roles in the pathogenesis, prognosis, gene and protein modifications, regulation of resistance to cytotoxic drugs and immunotherapies, and potential therapeutic applications. Nitric Oxide and Cancer addresses the burgeoning interest in a rapidly advancing field, and serves as both a valuable resource for scientists, clinicians, students, and health professionals and a reference for teaching and educational purposes.