Nitric Oxide: From Research to Therapeutics

ISBN-13: 9783031247774 / Angielski

Arunabha Ray; Kavita Gulati

Opis

This book entitled "Nitric Oxide: From Research to Therapeutics" includes the most recent information about the role of Nitric Oxide (NO) in physiology, pathophysiology and its translation to therapeutics. The Editors are vastly experienced in the field of NO research. The international panels of contributors to the various chapters of the book are all well-established researchers and health professionals who have worked in different areas of NO physiology and pathophysiology, and have made a considerable impact in the field. The book is a comprehensive collection of the most recent information on NO as a physiological regulator and its diverse potential as a therapeutic target for the treatment for a variety of disease states. This compilation is aimed at professionals and students from both academia and the industry in the areas of basic biomedical and clinical sciences.

Spis treści

1.      Translating Nitric Oxide Research to therapeutics: a critical appraisal

2.      Nitric oxide and cardiovascular health

3.      Nitric oxide and cardiovascular diseases: Cardioprotection, Complications and Therapeutics

4.      Nitric Oxide and the Heart Autonomic Nervous System

5.      Exercise induced NO modulation in prevention and treatment of cardiovascular diseases

6.      Nitric Oxide and Cardio-renal Syndrome

7.      Nitric Oxide-cGMP-PKG Signaling in the Cardioprotective Effect of cGMP Specific Phosphodiesterase 5 Inhibitors

8.      Role of Nitric Oxide Synthases in Doxorubicin-Induced Cardiomyopathy

9.      Role of Nitric Oxide Synthase and Nitric Oxide Signaling in the Neutrophil Ontogeny and Functions

10.  Cell Death- NO-today: Effect of NO and RNS on non-apoptotic regulated cell death

11.  Involvement of nitric oxide in insulin secretion to carbohydrate metabolism

12.  Nitric Oxide : a diagnostic tool and therapeutic strategy in Respiratory Diseases

13.  Therapeutic potential of nitric oxide in the management of COVID-19 induced Acute Respiratory Distress Syndrome (ARDS) 

14.  Emerging Novel Therapies for COVID-19: Implications for the Use of Nitric Oxide as Anti-COVID-19 Therapy

15.  Sex differences in stress and stress related neuropsychiatric disorders: Focus on nitric oxide

16.  Nitric oxide in major depressive disorder

17.  Role of Nitric Oxide in Alzheimer`s Disease : Perspectives and Trends

18.  Nitric oxide in Parkinson’s Disease: Insights into research and therapeutics

19.  Stable gastric pentadecapeptide BPC 157 and NO-system

20.  Exploring the gastroprotective, ulcer healing and chemopreventive properties of nitric oxide-releasing nonsteroidal anti-inflammatory drugs

21.  The role of nitric oxide in the etiopathogenesis of pre-eclampsia

22.  Therapeutic Prospects of Nitric Oxide as an Anti-Teratogen

23.  Ruthenium Nitrosyl Complexes: Photoinduced Delivery of NO to Different Biological Targets

24.  Nitric Oxide regulation in Microparticle

O autorze

Prof. Arunabha Ray is Head, Dept. of Pharmacology, Hamdard Institute of Medical Sciences and Research (HIMSR), Hamdard University, New Delhi, India. He was formerly Director, Vallabhbhai Patel Chest Institute, University of Delhi, Director-Professor and Head, Department of Pharmacology at Vallabhbhai Patel Chest Institute, University of Delhi, and Dean, Faculty of Medical Sciences, University of Delhi. Prof. Ray graduated in Medicine from the University of Calcutta and subsequently obtained MD and PhD degrees in Pharmacology from the Faculty of Medicine, University of Delhi. He has more than 40 years of teaching and research experience in basic and clinical pharmacology and allied biomedical sciences. He received postdoctoral training in universities and institutes in Canada and USA and specialized in research skills in the area of neuropharmacology and immunopharmacology. During his academic career, he has mentored research of several postgraduate and doctoral students as well as postdoctoral fellows, who have later proceeded to make a mark for themselves as successful researchers/professionals in their chosen fields. Prof. Ray is internationally recognized as one of the leading exponents in the area of nitric oxide (NO) research. He showed through his innovative research that NO played a significant role as an endogenous regulatory molecule during stress and proposed NO mediated signaling pathways for stress induced anxiogenesis, immunomodulation, and gastric ulceration, as well as for stress adaptation. Prof. Ray continues to be a prolific researcher, and his research has been recognized at the highest level which has led to several awards, honors and fellowships. Prof. Ray has been invited to several global scientific platforms (most notably to several IUPHAR meetings), international academic institutions/universities to deliver lectures on his area of research expertise and has been the recipient of several honors/awards/fellowships throughout his career for his professional excellence. He has had collaborations with research laboratories in the academia and pharmaceutical industry both at the national and international levels and has been Visiting Professor to many reputed institutions/universities. He is chairperson and expert member at several national academic/scientific committees at leading institutions/universities/organizations and plays a key role in guiding ethical scientific research in basic and clinical pharmacology as well as allied areas. He has been actively associated with several professional bodies/societies in pharmacology as well as allied fields. Most notably, Prof. Ray is the President of the Society for Nitric Oxide and Allied Radicals (SNOAR) which was established by his initiative in 2011 for advancement of research in Nitric Oxide (NO) and allied radicals and organized several scientific meetings on the subject matter. He has more than 250 scientific publications (research papers, reviews, monographs, book chapters), has edited several reference books and authored a Textbook in Pharmacology.

Prof. Kavita Gulati is Director-Professor in Pharmacology at Vallabhbhai Patel Chest Institute, University of Delhi. She is an M.Sc in Pharmacology from the AIIMS, New Delhi, and subsequently Ph.D. from the Faculty of Medicine, University of Delhi. Dr. Gulati has 30 years of teaching and research experience in Clinical & Experimental Pharmacology and Toxicology in different capacities in India and abroad. She is recipient of several national awards including the Achari Prize, Uvnas Prize and the prestigious Prof. B.N. Ghosh Oration of the Indian Pharmacological Society. Her research interests are cardio-respiratory pharmacology & toxicology, traditional medicine and stress research, with specific reference to nitric oxide (NO). In recognition of her contributions to the medical sciences she is elected as Fellow of NAMS (India) and IACS (Canada). She is life member of several professional bodies/societies relating to pharmacology and allied sciences. She is the Principal Investigator of several extramurally funded research projects and has the distinction of being invited to present talks at prestigious international meetings like IUPHAR, IACS, CMB Congress, World Stress Congress, and CPT Congress, International Immunology Congress etc.. She has been visiting scientist to several reputed international institutions like Semmelwies Medical University (Budapest, Hungary), University of Pittsburgh Medical Center (USA), Army Medical Institute (Xian, China), University of Minnesota at Minneapoilis (USA), University of Illinois at Chicago (USA), University of Manitoba (Canada), West Cape University (South Africa), University of Zagreb (Croatia) etc. and expert member at different Institutions and Government organizations in her field. She has published extensively in leading national and international journals (more than 250 publications), is co-author of several chapters in reference and textbooks of Pharmacology, and co-editor of four books in Pharmacology.