New concepts in pharmacological modulation of the of RAAS axis

ISBN-13: 9783659699689 / Angielski / Miękka / 2015 / 56 str.

Mandavia Chirag

Opis

This book provides a detailed review of the biological importance of the renin-angiotensin-aldosterone (RAAS) axis in the maintenance of human physiological functions and blood pressure homeostasis, and its regulation and manipulation via currently available pharmacological methods. In addition, this book review targets both the beneficial and detrimental effects of the RAAS axis in the context of cardiovascular and renal pathology, collectively termed the cardio-renal metabolic syndrome. Signaling pathways and direct interactions leading to crosstalk between RAAS and other growth and metabolic pathways are explored. Pharmacological means targeting the various components of the RAAS, including angiotensin receptor blockers, ACE inhibitors, aldosterone receptor antagonists and others are discussed.

O autorze

Dr. Chirag H. Mandavia has an MD degree in Medicine and MS degree in Molecular Biology. He has worked on several projects in the fields of Molecular Biology and Biochemistry, and most recently worked as a PostDoctoral Fellow at the University of Missouri School of Medicine. He has published several articles in US and international science journals.