New Trends in Hepatology: The Proceedings of the Annual Meeting of the Italian National Programme on Liver Cirrhosis and Viral Hepatitis, San Mi

ISBN-13: 9789401066464 / Angielski / Miękka / 2011 / 352 str.

P. Gentilini; M. U. Dianzani

Opis

This book contains papers from members of the Italian Group for the Study of Liver Cirrhosis and Viral Hepatitis, formed in 1980 on the basis of recognition and financial support from the Italian Ministry of the University. The primary initiative of the group is to combine experimental and clinical approaches in the study of liver pathophysiology. We have gathered specific experiences of all the centers included in the national program. Each group was required to present an update in its own field of research, rather than specific or recently obtained results which could have been reported only in relationship with data already published by others. This volume affirms the specific competence of all the participants and summarizes the most important updates in liver pathophysiology. The volume is divided into 5 sections dealing with different aspects of liver pathophysiology. Many contributions focus on the pathophysiology of liver injury and on clinical and pathogenetic aspects of hepatitis C virus infection, which today are representative of emergent fields. Other important aspects include the pathophysiology of liver cancer and clinical and therapeutic approaches in liver cirrhosis.

Spis treści

Foreword. Section 1: Pathogenetic Mechanisms of Liver Injury. 1. 4-Hydroxy Alkenals, Products of Lipid Peroxidation, as Signals for Biochemical Functions of Normal Cells; M.U. Dianzani. 2. Oxidative Stress and Protein Kinase C Activity Modulation; C. Domenicotti, et al. 3. Oxidative Damage in Chronic Liver Disease; E. Baldi, et al. 4. Chronic Ethanol Consumption Impairs Dolichol Levels and Glycosylation Processes in Rat Liver Microsomes and Golgi Apparatus; D. Cottalasso, et al. 5. Compartmentation and Redox State of Thiols and Proteins During Acute Ethanol Intoxication in Rats; E. Altomare, et al. 6. Possible Role of Ethanol-Derived Free Radicals in the Pathogenesis of Alcohol-Induced Liver Damage; E. Albano, et al. 7. Hepatic Iron Overload Induced by Phenylhydrazine: Release of Iron in a Free Form and DNA Damage; M. Comporti, et al. 8. The Effects of Development of the MDR 1 Phenotype on Cell Susceptibility to Undergoing Lipid Peroxidation and Ionizing Radiation; R. Mazzanti, et al. 9. Molecular and Cellular Aspects of Iron-Mediated Liver Toxicity; A. Pietrangelo, et al. 10. The Cellular and Molecular Basis of Liver Fibrogenesis; M. Pinzani, et al. 11. Proliferation of Hepatic Stellate Cells and Lipid Peroxidation: Changes Due to Polyphenols; G. Svegliati Baroni, et al. 12. Reoxygenation Injury in Isolated Rat Hepatocytes; P. Caraceni, et al. 13. Oxidative Stress and Cell Damage Following Orthotopic Liver Transplantation; E. Chiarpotto, et al. 14. The Genomic Response of Liver Cells to Post-Ischemic Reperfusion and Oxidative Stress; A. Bernelli-Zazzera. Section 2: Pathophysiology of Bile Secretion. 15. Cytotoxic and Protective Effects of Bile Salts in Vitro; F. Carubbi, et al. 16. Lamellar Bodies in Human Gallbladder Bile; S. Ginanni Corradini, et al. 17. Hepatocyte Lipid-Metabolic Interplays and the Cholesterol Secretion Process to Bile: Insights from Rat Studies; M. Carrella. Section 3: Insights in Hepatic Carcinogenesis. 18. Lipid Peroxidation and Hepatocarcinogenesis: &ggr;-Glutamyl Transpeptidase-Dependent Oxidant Stress in Hepatic Preneoplastic Lesions and HEPG2 Hepatoma Cells; A. Pompella, et al. 19. Antioxidant System in Hepatocellular Carcinoma; A. Grattagliano, et al. 20. Loss of Heterozygosity of the Long Arm of Chromosome 16 in Hepatocellular Carcinoma on Liver Cirrhosis; L. Gramantierei, et al. 21. Potential Molecular Mechanisms of Viral Liver Carcinogenesis; M.S. De Mitri, et al. 22. Prevalence of Wild-Type and Variant Transcripts of Liver Estrogen Receptors in Chronic Liver Disease; E. Villa, et al. Section 4: Pathogenetic Aspects of Hepatitis C Virus (HCV) Infection. 23. Molecular Biology of HCV: Implications in Epidemiology and Diagnosis of Infection; M. Rapicetta, et al. 24. Cell-Mediated Immune Response in Hepatitis C Virus (HCV) Infection: Are Different Strategies Adopted by HCV and Hepatitis B Virus to Persist?; F. Fiaccadori, et al. 25. The Epidemiological and Clinical Aspects of Hepatitis C in Italy; F. Morisco, et al. 26. Diagnostic Evaluation of Patients with Chronic HCV Infection; S. Nardiello, et al. 27. Correlation Between Hepatitis C Virus RNA Levels i