New Strategies in Stroke Intervention: Ionic Transporters, Pumps, and New Channels

ISBN-13: 9781617796623 / Angielski / Miękka / 2012 / 254 str.

Annunziato, Lucio

Opis

Ischemic brain damage represents a major source of morbidity and mortality in westernized society and poses a significant financial burden on the health care system. To date, few effective therapies have been realized to treat stroke and promising avenues have not proven clinically useful. Recent evidence, however, suggests that channels, pumps, and ionic exchangers are involved in CNS ischemia and ischemic stroke, but the potential contribution of these channels for curing stroke is far less understood than for many other normal and pathological conditions. New Strategies in Stroke Intervention: Ionic Channels, Pumps, and Transporters analyzes the roles played by targets in stroke development and the potential action of drugs modulating these proteins. This book provides a groundbreaking review of these ionic channels, pumps, and transporters as regulators of neuronal ionic homeostasis, providing a better understanding of ischemic brain disorders and the new pharmacological avenues for a cure. It will be a useful tool for researchers working in this field, and any student interested in the physiological, pathophysiological, and pharmacological features of stroke damage. §About the Editor:§Lucio Annunziato is a professor of pharmacology in the School of Medicine at the University of Naples Federico II , Italy. He is coordinator of the University's neuroscience Ph.D. program and director of the Department of Neuroscience. He is also the president elect of the Italian Society of Neuroscience. Dr. Annunziato has authored more than 150 full papers and his scientific interest is mainly devoted to the molecular pharmacology of plasma membrane transporters and ionic channels involved in the pathophysiology of stroke. Most of his recent papers have appeared in the most qualified international journals in the field of ischemic neurodegeneration.

Recenzje

From the reviews:

"This book on ionic channels in cerebral ischemia is a very detailed analysis of the recent literature on the subject with a wide and in depth scope. The book is meant for the seasoned and trained brain ischemia researcher as well as neurologists with an avid interest in this area. ... this book is going to serve a wide purpose as a reference book and a read as you go book for physiologists, neuroscientists, neurologists, and neurosurgeons." (Joseph J. Grenier, Amazon.com, September, 2013)

"'New Strategies in Stroke Intervention' provides a succinct review of several novel concepts which might prove to be of ultimate clinical relevance in stroke management. ... Each chapter provides an index typically listing 50-150 references. The information provided will be understandable to clinicians who might not have extensive genetic, molecular or biophysiological or pharmacological backgrounds. ... will be of particular interest to Stroke clinicians and Fellows and to other Neuroscientists engaged in brain ischemia research." (Christopher Voll, Le Journal Canadien Des Sciences Neurologiques, Vol. 37 (6), November, 2010)

"New Strategies in Stroke Intervention provides an in-depth summary of the present understanding of most of the major ion channels, pumps, and transporters, implicated in ischaemic neuronal death ... . it will provide an important reference on the pathophysiology of stroke for those with an interest in stroke medicine. This book succinctly summarises a large amount of published work and will provide a useful grounding for readers, as new discoveries are made." (Neil Spratt, The Lancet Neurology, Vol. 9, July, 2010)

Spis treści

Table of Contents: Preface Chapter 1. Basis of Ionic Dysregulation in Cerebral Ischemia Thiruma V. Arumugam, Eitan Okun, and Mark P. Mattson Chapter 2. Why have ionotropic and metabotropic glutamate antagonists failed in stroke therapy? Gianfranco Di Renzo, Giuseppe Pignataro, Lucio Annunziato Chapter 3. Mitochondrial channels as potential target for a pharmacological strategies in brain ischemia. Rosemary H. Milton and Michael R. Duchen Chapter 4. Endoplasmic Reticulum Calcium Homeostasis and Neuronal Pathophysiology of Stroke Alexei Verkhratsky Chapter 5. The Na(+)/Ca(2+) Exchanger: a target for therapeutic intervention in cerebral ischemia Lucio Annunziato, Pasquale Molinaro, Agnese Secondo, Anna Pannaccione, Antonella Scorziello, Giuseppe Pignataro, Ornella Cuomo, Rossana Strabella, Francesca Boscia, Alessandra Spinali, Gianfranco Di Renzo Chapter 6. The 'loop' Diuretic Drug Bumetanide-sensitive Na+-K+-Cl - Cotransporter in Cerebral Ischemia Dandan Sun Chapter 7. The Na(+)/H(+) exchanger: a target for therapeutic intervention in cerebral ischemia Jin Xue and Gabriel G. Haddad Chapter 8. The Na+/K+-ATPase as a drug target for ischemic stroke Melissa A. Gottron and Donald C. Lo Chapter 9. Acid-Sensing Ion Channels (ASICs): New Targets in Stroke Treatment Giuseppe Pignataro Chapter 10. Role of TRPM7 in Ischemic CNS Injury Michael F. Jackson, Hong-Shuo Sun, Michael Tymianski, and John F. MacDonald Chapter 11. Subtypes of voltage-gated Ca2+ channels and ischemic brain injury Soon-Tae Lee, Daejong Jeon, and Kon Chu Chapter 12. The diverse roles of K+ channels in brain ischemia Hiroaki Misonou and James S. Trimmer Chapter 13. Clinical Trials with Drugs Targeting Ionic Channels, Antiporters, and Pumps in Ischemic Stroke Alessandra Spinali, Giuseppe Pignataro, Gianfranco Di Renzo, Lucio Annunziato