New Strategies Targeting Cancer Metabolism: Anticancer Drugs, Synthetic Analogues and Antitumor Agents

ISBN-13: 9780128217832 / Angielski / Miękka / 2022

Galal Elgemeie; Reham Mohamed-Ezzat

Spis treści

1. Medicinal chemistry of anticancer agents 2. Folate-based anticancer drugs 3. Purine-based anticancer drugs 4. Pyrimidine-based anticancer drugs 5. Synthetic strategies for anticancer antifolates 6. Synthetic strategies for purine nucleoside analogues 7. Synthetic strategies for pyrimidine nucleoside analogues 8. Anticancer alkylating agents 9. Natural products as anticancer agents 10. Synthetic strategies for antimetabolite analogues in our laboratory

O autorze

Galal H. Elgemeie is the author of over 270 scientific international papers on heterocyclic chemistry and medicinal chemistry. His research interests include the development and mechanistic understanding of organic reactions and their application to the synthesis of antimetabolic agents. He was an international elected member of the Scientific Board of the International Basic Sciences Programme (IBSP), UNESCO, in Paris, France. He was a postdoctoral fellow of the Alexander von Humboldt Foundation in Germany, the Fulbright in USA, the British Council in England, and then the German Research Foundation (DFG) in Germany. He supervised several cooperation projects with the European Community under the TEMUPS programme, Prof. Elgemeie was nominated as one of the leading scientists of the COMSTECH in the year 2009 Report. Prof. Elgemeie's research activities have received many awards including The African Union Scientific Award "Continental Scientific Award" in Science and Technology, The ISESCO Scientific Award and The Egypt State Honor Award "NILE", among many others. Reham A. Mohamed-Ezzat is a researcher in the Chemistry of Natural and Microbial Products Department, Pharmaceutical & Drug Industries Research Division, National Research Center in Egypt. She got her B.Sc (2010) in Chemistry & Biochemistry-Faculty of Science. She was awarded her M.Sc. (2015) & PhD degree of science in organic chemistry in 2019 from Helwan University. She has published many books and articles in international journals in the field of bioorganic and medicinal chemistry. She has extensive experience in the field of design and synthesis of novel molecules of medicinal application, as well as the implementation of new strategies in the syntheses of bioactive compounds.