New Insights Into Glioblastoma: Diagnosis, Therapeutics and Theranostics

ISBN-13: 9780323998734 / Angielski / Miękka / 2023

Carla Vitorino; Carmen Balana; Célia Cabral

Opis

New Insights into Glioblastoma: Diagnosis, Therapeutics and Theranostics provides a compendium of recent diagnostic and therapeutic advances in GBM, encompassing a pipeline of compounds and (bio) nanotechnology strategies that have stood out with potential increased antitumoral activity and capability to cross the blood-brain barrier. Issues and challenges related to their translation into the clinical practice and their contribution to the increase in survival rates and well-being of patients are addressed. This is a valuable resource for graduate students, oncologists, cancer researchers and members of the biomedical field who need to learn more on recent developments on the management of glioblastoma. The book is split in three parts: Diagnosis, focusing on biomarkers and techniques such PET/MRI, infrared thermography, and deep neural networks; Therapeutics, discussing new chemical entities, as natural products and repurposed drugs, and new formulation approaches, as nanotechnology-based and microRNA approaches; and Theranostics, explaining the role of omics, system-based approaches, and glioblastoma microenvironment.

Spis treści

I. Introduction1 Introduction: A brief outlook into glioblastoma diagnosis and therapeutics

II. DiagnosisII.1 Biomarkers2. Practice guidelines for the diagnosis of glioblastoma3. Identification of potential biomarkers in glioblastoma through OMICS technologies and Big Data Analysis4. Forging a path to the use of liquid biopsy in the diagnosis of gliomas 5. Secretome analysis of patient-derived glioblastoma cells for potential biomarker identificationII.2 Techniques: updates6. Newly diagnosed glioblastoma: a review on clinical management7. Current status in brain glioma imaging (MRI, CT-Scan)8. Combined PET/MRI in brain glioma imaging9. New surgical approaches in glioblastoma10. The role of radiogenomics

III. TherapeuticsIII.1 New chemical entities11. An overview of molecular targeting of glioblastoma12. Terpenes: a hope for glioblastoma patients13. The artificial intelligence contribution to speed-up the active compounds screening14. Repurposing drugs in glioblastoma15. Glioblastoma heterogeneity and resistance: a glance in biology and therapeutic approach16. Targeting DNA damage response pathways in glioblastoma: from mechanistic insights to advances in the clinic17. Alkaloids: their relevance in cancer treatmentIII.2 New formulation approaches18. An overview of current drug delivery strategies for glioblastoma treatments and barriers to progress19. Nanotechnology-based approaches in glioblastoma treatment: how can the dual blood brain/tumor barriers be overcome?20. Non-coding RNAs in glioblastoma at a glance21. The role of vaccines in glioblastoma - updated clinical results22. Dendritic cells and glioblastoma23. Cancer stem cells in glioblastoma - an update24. Optimizing the role of immunotherapy for treatment of glioblastoma25. The role of exosomes in glioblastoma treatment

IV. Theranostics26. Theranostic in glioblastoma27. Potential theranostic targets in glioblastoma 28. Radiopharmaceuticals for molecular imaging and theranostics of glioblastoma29. Theranostic strategies synergistically potentiate glioblastoma treatment via nanotechnology30. The effect of glioblastoma microenvironment on theranostics