New Frontiers in Regenerative Medicine

ISBN-13: 9784431382072 / Angielski / Twarda / 2007 / 154 str.

Mitsuo Kusano; Seiji Shioda

Opis

Rapid advances in stem cell biology have raised exciting possibilities of replacing damaged or lost tissues and cells by activation of in vitro-expanded stem cells or their progeny. This book examines many of the unresolved problems as well as future applications of regenerative medicine. Areas of focus include the nervous system and hippocampal neurogenesis, along with the functional significance of pro-inflammatory cytokines, and the production of free radicals after brain ischemia; the digestive and integumentary systems, dealing with hepatocyte transplantation, pancreatic regeneration, and skin and hair regeneration; and the cardiovascular system, with repair and remodeling of the lung and heart, and arterial remodeling with bone marrow-derived progenitor cells. In addition to animal experiments, results of research on human tissues and organs are included. Researchers in the field will find this volume an invaluable source of reference in their work.

Spis treści

Digestive and Integumentary System.- Hepatocyte transplantation for liver disease.- Liver regeneration with the resolution of fibrosis by bone marrow cell infusion therapy.- Cryopreservation of hepatocytes -Is it effective to cryopreserved hepatocytes using a new cryopreservation procedure combining a bioartificial approach? -.- Induction of Hair Re-growth by Protein Kinase C ?.- Novel Model for Evaluation of Human Skin Injury.- Heparin enhances BMP activity by maintaining high levels of nuclear phosphorylated Smad1/5/8.- The Cardiovascular System.- Vascular engraftment and repair by adult non-hematopoietic stem/progenitor cells.- Importance of Neutrophil and Erythroblast for the efficacy of Bone-marrow Cell Implantation in Peripheral Artery Disease.- Bone marrow derived cells contribute to arterial remodeling.- TNF-? mobilizes bone marrow derived cells to vascular wall, resulting in neointima formation through its inflammatory effects.- Angiogenesis induced by adhesion between polymorphonuclear leukocyte and endothelial cell via intercellular adhesion molecule-1.- Improvement of severe ulcer of buerger’s disease by bone-marrow mononuclear cell transplantation: a case report.- Cardioprotective effect of G-CSF administration after coronary reperfusion in swine AMI model.- The Nervous System.- Adult neurogenesis in the hippocampus.- Involvement of ? Isoform of PKC in PACAP-induced Differentiation of Neural Stem Cells into Astrocytes.- Does PACAP have therapeutic potential in the field of neuroregenerative medicine?.- The Surgical Procedures of Hippocampal Ischemia Models for the Study of Regeneration in Rats.