New Directions in Cancer Treatment

ISBN-13: 9783540190639 / Angielski / Miękka / 1989 / 631 str.

Ian T. Magrath; K. H. Antman

Opis

During the last few decades, there has been a tremendous improvement in the treatment of cancer. There is evidence that this trend is continuing, based on the achievements re sulting from the combined efforts of clinicians and basic re search workers. This book is an example of such interaction and collaboration. It was prepared by authors representing both areas of work. Most of the work reported in this book is not merely theoretical, but has been experimentally successfully tested and sometimes applied clinically. This work has, however, not yet been generalized and practiced on a wide scale. Some of the results reported here relate to new aspects and open new horizons for future progress. This book will be of great value for both clinicians and basic research workers. VICC Treatment and Rehabilitation Programme ISMAIL ELSEBAI Chairman Preface The three main approaches to the treatment of cancer are surgery, radiotherapy, and chemotherapy. Today, all malignant neoplasms are managed by one or more of these modalities, with varying success rates depending on the type of tumor, its degree of spread, and the knowl edge and skill with which the treatment plan has been designed and executed. In the United States of America and in Europe, approximate ly half of all cancer is presently curable, but this has been the case for approximately 20 years."

Spis treści

1. New Directions in Cancer Treatment: An Overview.- Physical Approaches to Therapy.- 2. New Approaches in Radiation Therapy.- 3. Radiotherapy Treatment Planning: Past, Present, and Future.- Color Plates I–VII (following p. 78).- 4. Hyperthermia as Cancer Therapy: Current Status and Future Prospects.- 5. Photodynamic Therapy.- Chemotherapy.- 6. Very High Dose Therapy in Lymphomas and Solid Tumors.- 7. Allogeneic Marrow Transplantation for Malignancy—Current Problems and Prospects for Improvement.- 8. Regional Therapies.- 9. Drug Resistance in Cancer.- 10. Multidrug Resistance in Tissue Culture and Human Tissues.- 11. Development of New Chemotherapeutic Agents.- 12. New Drug Trials.- 13. Drug Delivery to Brain Tumors.- Biological Approaches to Therapy.- 14. The Evaluation of Biological Response Modifiers for Cancer Therapy.- 15. Biologic Response Modifiers in Cancer Therapy.- 16. The Potential Value of Radiolabelled Monoclonal Antibodies in Cancer Therapy.- 17. Monoclonal Antibody Conjugates with Cytotoxic Agents for Cancer Therapy.- 18. Bone Marrow Purging.- 19. Future Prospects for the Treatment of Hormone-Responsive Tumors.- Potential Approaches.- 20. Tumor Invasion and Metastases: Biochemical Mechanisms.- 21. Prospects for the Development of Antineoplastic Therapy Based on Molecular Pathology.- 22. Differentiation of Malignant Cells as a Strategy for Cancer Treatment.- Therapeutic Trends in Specific Neoplasms.- 23. Malignant Brain Tumors.- 24. Head and Neck Cancer.- 25. Lung Cancer.- 26. Breast Cancer.- 27. Renal Cell Carcinoma.- 28. Carcinoma of the Pancreas.- 29. Hepatocellular Carcinoma.- 30. Esophageal Carcinoma.- 31. Gastric Cancer.- 32. Colon Cancer.- 33. Bladder Cancer.- 34. Prostate Cancer.- 35. Advanced Germ Cell Tumors.- 36. Ovarian Cancer.- 37. Trophoblastic Neoplasia.- 38. Malignant Adrenal Tumors.- 39. Neuroendocrine Tumors.- 40. Soft Tissue Sarcomas in Adults.- 41. Melanoma.- 42. Basal Cell Carcinoma.- 43. Acute Lymphoblastic Leukemia.- 44. Acute Nonlymphoblastic Leukemia.- 45. The Chronic Leukemias.- 46. Hodgkin’s Disease.- 47. Plasma Cell Myeloma.- 48. Follicular Non-Hodgkin’s Lymphomas.- 49. Diffuse Aggressive Lymphomas in Adults.- 50. Childhood Non-Hodgkin’s Lymphomas.- 51. Osteosarcoma.- 52. Ewing’s Sarcoma.- 53. Soft Tissue Sarcomas in Childhood.- 54. Wilms’ Tumor.- 55. Neuroblastoma.- 56. Retinoblastoma.