New Concepts of Antiviral Therapy

ISBN-13: 9780387310466 / Angielski / Twarda / 2006 / 538 str.

Elke Bogner; Andreas Holzenburg

Opis

Antiviral drugs are important tools for treatment or prevention of viral infections. These drugs were first used for monotherapy, but nowadays combinations of antiviral agents are often part of a standard treatment as evidenced by e.g. HAART (highly active antiretroviral therapy). However, in almost every case of antiviral therapy, drug resistant viruses appear. In addition, the low oral bioavailability, toxicity and the number of severe side effects still pose significant problems. All of the latter issues limit the clinical usefulness and drive the need for improved antiviral strategies. These strategies include new drugs and targets, novel modes of action, vector-based treatments and even the block of defined genes by inhibiting mRNA formation (siRNA). Highlights of this book include the discussion of: - novel, promising compounds - concepts of therapy for new/emerging viruses - managing drug resistance - new therapeutic strategies This book presents an overview of the most recent developments. Contributions were carefully selected to ensure quality coverage by acknowledged experts over a wide spectrum and should prove to be of great value to students and serve as a compendium for R and D and educational professionals.

Spis treści

Contents Part 1. Concepts of therapy for RNA viruses Therapeutic vaccination in chronic hepadnavirus infection by Michael Rogendorf and Mengji Lu Characterization of targets for antiviral therapy of Flaviridae infections by Peter Borowski Inhibition of Hepatitis C virus by nucleic acid-based antiviral approaches by Michael Frese and Ralf Bartenschlager Inhibitors for respiratory viruses by Ernst Kuechler and Joachim Seipelt Anti-viral approaches against influenza viruses by Stephan Pleschka, Stephan Ludwig, Thorsten Wolff and Oliver Planz A new approach to an Influenza virus live vaccine: Modification of the cleavage site of the haemagglutine by reverse genetics by Jürgen Stech, Holger Garn and Hans-Dieter Klenk New concepts in anti-HIV therapies by Justin Stebbing, Mark Bower and Brian Gazzard Evaluation of current strategies to inhibit HIV entry, integration and maturation by Jaqueline D. Reeves, Stephen D. Barr and Stephan Pöhlmann Managing antiretroviral resistance by Barbara Schmidt, Monika Tschoschner, Hauke Walter and Klaus Korn Part 2. Concepts of therapy for DNA viruses Selective inhibitors of the replication of poxviruses by Johan Neyts and Erik de Clercq Maribavir: A promising new antiherpes therapeutic Agent by Karen K. Biron Benzimidazle-D-ribonucleosides as antiviral agents that target HCMV terminase by John C. Drach, Leroy B. Townsend and Elke Bogner Recent developments in anti-herpesviral therapy based on protein kinase inhibitors by Thomas Herget and Manfred Marschall Immune therapy against papillomavirus-related tumors in humans by Lutz Gissmann Part 3. Concepts of therapy for emerging viruses The SARS Corona virus receptor ACE-2 A potential target for antiviral therapy by Jens H. Kuhn, Sheli R. Radoshitzky, Wenhui Li, Swee Kee Wong, Hyeryun Choe and Michael Farzan Therapy of Ebola and Marburg virus infections by MikeBray Part 4. General concepts of therapy Proteasome inhibitors as complementary or alternative antiviral therapeutics by Susanna Prösch and Marion Kaspari Human monoclonal antibodies for prophylaxis and therapy of viral infections by Jan ter Meulen and Jaap Goudsmit Vector-based antiviral therapy by Armin Ensser Index

O autorze

Antiviral drugs are vital, but imperfect tools for treatment and prevention of viral infections. Undesirable effects, from drug resistant viruses to low oral bioavailability, toxicity and severe side effects limit clinical usefulness. All these issues drive the need for improved antiviral strategies. This book offers an up-to-date review of new drugs and targets, novel modes of action, vector-based treatments and even the blocking of defined genes by inhibiting mRNA formation (siRNA). Highlights include the discussion of novel, promising compounds; concepts of therapy for new/emerging viruses; managing drug resistance; new therapeutic strategies. Contributions were carefully selected to ensure quality coverage by acknowledged experts over a wide spectrum and will be of great value to students and serve as a compendium for R&D and educational professionals.