Neutron Scattering in Biology: Techniques and Applications

ISBN-13: 9783642067075 / Angielski / Miękka / 2010 / 560 str.

Jorg Fitter; Thomas Gutberlet; John Katsaras

Opis

The advent of new neutron facilities and the improvement of existing sources and instruments world wide supply the biological community with many new opportunities in the areas of structural biology and biological physics. The present volume offers a clear description of the various neutron-scattering techniques currently being used to answer biologically relevant questions. Their utility is illustrated through examples by some of the leading researchers in the field of neutron scattering. This volume will be a reference for researchers and a step-by-step guide for young scientists entering the field and the advanced graduate student.

Spis treści

Neutron Scattering for Biology.- Neutron Scattering for Biology.- Elastic Techniques.- Single Crystal Neutron Diffraction and Protein Crystallography.- Neutron Protein Crystallography: Hydrogen and Hydration in Proteins.- Neutron Protein Crystallography: Technical Aspects and Some Case Studies at Current Capabilities and Beyond.- Detergent Binding in Membrane Protein Crystals by Neutron Crystallography.- High-Angle Neutron Fiber Diffraction in the Study of Biological Systems.- Neutron Scattering from Biomaterials in Complex Sample Environments.- Small-Angle Neutron Scattering from Biological Molecules.- Small Angle Neutron Scattering from Proteins, Nucleic Acids, and Viruses.- Structure and Kinetics of Proteins Observed by Small Angle Neutron Scattering.- Complex Biological Structures: Collagen and Bone.- Structural Investigations of Membranes in Biology by Neutron Reflectometry.- Protein Adsorption and Interactions at Interfaces.- Complex Biomimetic Structures at Fluid Surfaces and Solid-Liquid Interfaces.- Inelastic Techniques.- Quasielastic Neutron Scattering in Biology, Part I: Methods.- Quasielastic Neutron Scattering in Biology, Part II: Applications.- Conformational Dynamics Measured with Proteins in Solution.- Relating Protein Dynamics to Function and Structure: The Purple Membrane.- Biomolecular Spectroscopy Using Pulsed-Source Instruments.- Brownian Oscillator Analysis of Molecular Motions in Biomolecules.- Internal Dynamics of Proteins and DNA: Analogy to Glass-Forming Systems.- Structure and Dynamics of Model Membrane Systems Probed by Elastic and Inelastic Neutron Scattering.- Subnanosecond Dynamics of Proteins in Solution: MD Simulations and Inelastic Neutron Scattering.