Neurotransmitters and Drugs

ISBN-13: 9780412361104 / Angielski / Miękka / 1991 / 204 str.

Zygmunt L. Kruk; Z. L. Kruk; C. Pycock

Opis

This book is intended for students of medicine, pharmacy and other biological disciplines, who want to have a working knowledge of the mechanisms of action, uses and adverse effects of drugs which modify the activity of neurotransmitters in the peripheral and central nervous systems. It is suitable for undergraduates and for post-graduates on taught higher degree courses and diplomas. New information and concepts have been incorporated into the text as appropriate, and references have been updated. Excitatoryand inhibitory amino acids are considered in two chapters, and the last chapter of the first two editions (which considered drugs which do not interact selectively with neurotransmitters) has been subsumed into other sections. The third edition follows the tried format of previous editions. Following a chapter which introduces the biology and pharmacology of neurotransmission, subsequent chapters deal with synthesis, storage, release, receptors and inactivation of individual neurotransmitters, together with a consideration of therapeutic uses and mechanisms of adverse effects.

Recenzje

From reviews of previous editions:; The structural organisation of the book is excellent. Trends in Neurosciences; The authors have produced a well thought out book, and as an adjunct to more detailed texts, I would recommend this book to second year pharmacology, and medical students. Biochemical Society Transactions; During its brief existence, Neurotransmitters and Drugs has become a standard undergraduate text in pharmacology and is strongly to be recommended for the relevance of its material and clarity of its presentation. Journal of Clinical and Hospital Pharmacy; A good introduction to the pharmacology of neurotransmission, a subject which is yearly increasing in importance. The prose is economic, the style didactic and the result highly effective. British Journal of Psychiatry

Spis treści

1 Neurotransmission: Sites at which drugs modify neurotransmission.- 1.1 The neurone.- 1.2 Axonal transport.- 1.3 Neuronal cell membranes.- 1.4 Precursors.- 1.5 Synthesis.- 1.6 Storage.- 1.7 Organelles and enzymes.- 1.8 Release.- 1.9 Receptors.- 1.10 Inactivation.- 1.11 Neurotransmitters or neuromodulators.- 1.12 Neurotransmitters in the nervous system.- 1.13 Neurotransmitters and drugs.- Further reading.- 2 Acetylcholine.- 2.1 Synthesis.- 2.2 Storage.- 2.3 Release.- 2.4 Cholinergic receptors.- 2.5 Inactivation of acetylcholine.- 2.6 Therapeutic applications and consequences of drugs acting at cholinergic synapses.- Further reading.- 3 Noradrenaline.- 3.1 Synthesis.- 3.2 Storage.- 3.3 Release.- 3.4 Adrenoreceptors.- 3.5 Inactivation of noradrenaline.- 3.6 Therapeutic applications and consequences of drugs acting at noradrenergic synapses.- Further reading.- 4 Dopamine.- 4.1 Synthesis.- 4.2 Storage.- 4.3 Release.- 4.4 Dopamine systems.- 4.5 Inactivation of dopamine.- 4.6 Therapeutic applications and consequences of drugs acting at dopaminergic synapses.- Further reading.- 5 5-Hydroxytryptamine.- 5.1 Synthesis.- 5.2 Storage.- 5.3 Release.- 5.4 5-HT receptors.- 5.5 Inactivation of 5-HT.- 5.6 Therapeutic applications and consequences of drugs acting at 5-HT synapses.- Further reading.- 6 Histamine.- 6.1 Synthesis.- 6.2 Storage.- 6.3 Release.- 6.4 Histamine receptors.- 6.5 Inactivation of histamine.- 6.6 Therapeutic applications and consequences of drug action on histamine systems.- Further reading.- 7 Inhibitory amino acids: GABA, glycine and taurine.- 7.1 Amino acids as neurotransmitters.- 7.2 ?-aminobutyric acid.- 7.3 Glycine.- 7.4 Taurine.- Further reading.- 8 Excitory amino acids: L-glutamic acid and L-aspartic acid.- 8.1 Synthesis.- 8.2 Storage.- 8.3 Release.- 8.4 Excitatory amino acid receptors in the CNS.- 8.5 Inactivation of released excitory amino acids.- 8.6 Functional roles of cerebral excitory amino acid neurotransmitters.- Further reading.- 9 Peptides and neuronal function.- 9.1 Peptides as neurotransmitters and hormones.- 9.2 Synthesis, storage, transport, release and inactivation of neuropeptides.- 9.3 Co-existence and co-transmission of peptides with classical neurotransmitters.- 9.4 Opioid peptides.- 9.5 Substance P (the tachykinins).- 9.6 Cholecystokinin (CCK).- 9.7 Vasoactive intestinal polypeptide.- 9.8 Neurotensin.- 9.9 Somatostatin.- 9.10 Bombesin.- Further reading.