Neurotransmitter Receptors: Mechanisms of Action and Regulation

ISBN-13: 9781468448078 / Angielski / Miękka / 2012 / 297 str.

Shozo Kito

Opis

This meeting was held commemorating Dr. Kito's 10th Anniversary as Professor of the Third Department of Internal Medicine, Hiroshima University School of Medicine. Dr. Kito was born in 1927 in Nagoya, graduated from Tokyo University School of Medicine and received his M. D. in 1951. He spent his first academic years as a research associate (1952 - 1968) at the Third Department of Internal Medi- cine, Tokyo University School of Medicine. During this period he studied for one year (1952 - 1953) at Illinois University School of Medicine, and acquired his Ph. D. in 1959. In 1968 he became Instructor and in 1971 he was appointed as Assistant Professor of Tokyo Women's Medical College. In 1973, he became Professor of the Third Department of Internal Medicine, Hiroshima University School of Medicine. Dr. Kito is a clinician but he is always enthusiastic about basic medicine. His major research field concerns neurotrans- mitters and their receptors in the central nervous system. He prefers a combination of neurotransmitter immunohistochemistry and receptor autoradiography as research techniques. He is also engaged in biochemical studies on amyloid proteins. When the Eighth Inter- national Congress of Pharmacology was held in Tokyo in 1981, Dr. Segawa, Dr. Yamamura, and Dr. Kuriyama organized a Satellite Symposium on Neurotransmitter Receptors in Hiroshima. Dr. Kito attended this meeting and was deeply impressed by the active presentations and discussions. In order to make some contribution to the progress of neuro- sciences, Dr.

Spis treści

Coupling of Neurotransmitter Receptors to Adenylate Cyclase.- Selective Blockage by Islet-Activating Protein, Pertussis Toxin, of Negative Signal Transduction from Receptors to Adenylate Cyclase.- A Central Role for Magnesium in the Regulation of Inhibitory Adenosine Receptors.- Role of Hormone-Sensitive GTPases in Adenylate Cyclase Regulation.- Reconstitution of the Regulatory Functions of ?-Adrenergic Receptors.- Regulation of the Catalytic Unit of Adenylate Cyclase System in Rat Brain.- Molecular Regulatory Mechanism of D2 Dopamine Receptor in the Bovine Striatum.- Genetic and Functional Studies of Guanine Nucleotide-Binding Regulatory Proteins.- Regulation, Interactions, and Coupling to Effectors.- Differential Regulation of Putative M1/M2 Muscarinic Receptors: Implications for Different Receptor-Effector Coupling Mechanisms.- Factors Regulating Ligand Binding to 5-Hydroxytryptamine Receptors in Rat Brain.- Evidence for Alpha2-Adrenergic Receptors in Bovine Cerebral Arteries.- Modulation of Alpha2-Adrenergic Receptors of Rat Vas Deferens by Adenosine Receptors.- Neuromodulatory Roles of Adenosine Receptors Coupling to the Calcium Channel and Adenylate Cyclase.- Interaction of Enkephalin with Opioid Receptors of Brain Membranes: Regulation by Essential Transition Metals, Guanine Nucleotides and Temperature.- Ca2+-Activated, Fatty Acid-Dependent Guanylate Cyclase in Synaptic Plasma Membranes and Its Requirement for Ca2+ and Mg-GTP in the Activation.- Modulation of Neuroreceptor Functions by Lipomodulin, a Phospholipase Inhibitory Protein.- Receptor Structure, Localization, and Ion Channels.- Ontogenetic Development of the Specific [3H]Nitrendipine Binding Sites in the Rat Whole Brain.- Biochemical Properties of the GABA/Barbiturate/Benzodiazepine Receptor-Chloride Ion Channel Complex.- Purification of ?-Aminobutyric Acid (GABA) and Benzodiazepine Receptors from Rat Brain Using Benzodiazepine-Affinity Column Chromatography.- Structure and Properties of the Brain GABA/Benzodiazepine Receptor Complex.- Use of Autoradiographic Techniques for the Localization of Neurotransmitter Receptors in Brain and Periphery: Recent Applications.- The Structure and Evolution of Neurotransmitter Receptors (?- and ?-Adrenergic, Dopaminergic and Muscarinic Cholinergic).- Contributors.