Neurotoxicity of Metals

ISBN-13: 9783319601885 / Angielski / Twarda / 2017 / 383 str.

Michael Aschner; Lucio Costa

Opis

Assembles international authorities to address contemporary research in metal neurotoxicity. Essential and non-essential metals play an important role in neurodevelopmental and neurodegenerative diseases. Recent developments in understanding the role of metals in the etiology of these disorders have led to rapid growth in clarifying the pathology of some of the most devastating diseases we face and in identifying potential new therapies. Few books or periodicals have been wholly dedicated to the topic of metals, and this collection is intended to serve as a resource for all researchers interested in metals and their role in health and disease.

Spis treści

Aschner                                   Manganese and PD

Costa                                       Metals and paraoxonases

Fox                                           Pb and visual system

Guilarte                                   Pb (Mn) and neurodegeneration or Schizophrenia

Cory-Slechta    &nb

sp;            Pb and stress interactions in developmental neurotoxicity

Tjalkens                     Metals induced neuroinflammation

Brazilians                   MeHg and neurodegeneration

Grandjean                    MeHg developmental neurotoxicity

Lucchini                     Mn epi

Sanders (Mount Sinai)        Cadmium neurotoxicity

Bondy                   

;     Aluminum neurotoxicity

Syed Ali/Saber               Metal nanoparticles neurotoxicity    

Tony White                   Metals and AD

Aizenman                     Zinc and AD

Connor        Fe neurotoxicity

O autorze

Michael Aschner is the Gray E. B. Stahlman Professor of Pediatrics and Pharmacology at Vanderbilt University School of Medicine as well as a Senior Investigator at the Kennedy Center for Research on Human Development. Dr Aschner’s research group has a particular interest in the neurobiology and physiology of astrocytes and the signaling mechanisms associated with central nervous system injury. Dr Aschner’s laboratory studies metal uptake and distribution in the brain, investigating the mechanisms of transport of methylmercury and manganese across the capillaries of the blood–brain barrier. His research utilizes various experimental models (C. elegans, tissue cultures and rodents) to understand the acute toxicity of manganese deposition in the brains of human neonates.

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Lucio G. Costa is Professor of Environmental and Occupational Health Sciences at the School of Public Health at the University of Washington. Dr. Costa is a renowned neurotoxicologist whose research interests are focused on understanding the role of neurotoxic substances in neurodevelopmental disorders and other neurological, neuropsychiatric and neurodegenerative diseases. Dr Costa’s research laboratory makes use of a variety of in vivo and in vitro cell culture systems, transgenic animal models and imaging techniques to study the cellular, biochemical and molecular mechanisms of neurotoxicity.

Blurb

In this book, international authorities address contemporary research in metal neurotoxicity. Essential and non-essential metals play an important role in neurodevelopmental and neurodegenerative diseases. Recent developments in understanding the role of metals in the etiology of these disorders have led to rapid growth in clarifying the pathology of some of the most devastating diseases we face and in identifying potential new therapies. Few books or periodicals have been wholly dedicated to the topic of metals, and this collection is intended to serve as a resource for all researchers interested in metals and their role in health and disease.