Neuropsychopharmacology: Proceedings of the Xvith C.I.N.P. Congress, Munich, August, 15-19, 1988

ISBN-13: 9783642740367 / Angielski / Miękka / 2013 / 825 str.

W. E. Jr. Bunney; Hanns Hippius; Gregor Laakmann

Opis

In 1988, for the first time in its thirty years history, the Collegium Interna- tionale Neuropsychopharmacologicum (CINP) with one of its biannual congresses returned to the same city - to Munich. In Munich, 26 years ago (1962) the IIIrd CINP Congress had been held. A comparison of these two Munich CINP Congresses is evidence for the fruitful growing and expansion of research in basic and clinical neuropsychopharmacology. In 1988, more than 3000 people attended the XVIth CINP Congress. And it was necessary to have - besides poster presentations - up to fourteen parallel sessions. By decision of the Programme Committee (A. Coppen, E. Costa, H. Hippius, J. Mendlewicz, G. Racagni and I. Yamashita) 65 symposia to special topics had been accepted and were held during one week. These symposia were the core of the congress. Special scientific highlights of the congress were the four plenary sessions. There, lectures were presented by two Nobel Prize Laureates- G. Edelman and M. Eigen -and six other outstanding scientists (B. Sakmann and the CINP members W. E. Bunney, A. Carlsson, P. Janssen, M. Schou, G. Sedvall).With the aim to inform about the results of the XVIth CINP Congress as many scientists as possible, the CINP Executive Committee and the Pro- gramme Committee published in a separate volume the abstracts of all symposium-presentations, all platform- and poster-presentations (Psycho- pharmacology - Supplement to Volume 96 - Springer International 1988).

Spis treści

1 Introduction.- Perspectives on Dopamine as a Regulator of Brain Function.- A View of Psychopharmacology, Neuroscience, and the Major Psychoses.- Lithium Is All Right, but … About Some Misconceptions and Some Recent Findings.- Improvement in the Quality of Sleep: A New Goal in Psychopharmacology.- The Future of Psychopharmacology and Positron Emission Tomography.- 2 Molecular Biology in Neuropsychopharmacology.- Molecular Biological Approaches to Brain Region- and Cell-Specific Molecules.- The ?1-Adrenergic Receptor as a Paradigm of Receptors Coupled to Guanine Nucleotide Binding Proteins.- The Alpha-2 Adrenoceptor Vulnerability Hypothesis of Depression: From the Clonidine Growth Hormone Stimulation Test to the Genes Encoding a Human Alpha-2 Adrenoceptor and Phenylethanolamine N-Methyltransferase.- 3 Molecular Biology in Neurology and Psychiatry.- Genetic Linkage Analysis in Early-Onset Familial Alzheimer’s Dementia.- Molecular Genetic Approach in Affective Illness.- Molecular Genetic Studies in Affective Disorders.- 4 Brain Transplants in Neurology and Psychiatry.- Long-Term Changes in Parkinson’s Disease Patients with Adrenal Medullary Autografts to the Caudate Nucleus.- 5 Peripheral Cells as Pharmacological Models in Psychiatric Research.- Lymphocyte Cholinergic Receptor Changes in Alzheimer’s Disease.- Increased Platelet Membrane Fluidity in Alzheimer’s Disease: An Initial Assessment of Specificity.- [3H] Spiperone Binding to Lymphocytes in Psychiatric Disorders.- Platelet Binding Sites for Serotonin Uptake Inhibitors: Is [3H]Imipramine Binding Decreased in Depression?.- Changes in Platelet Serotonergic and Adrenergic Function in Patients with Depression, Panic Attack, and Mania.- Platelet Monoamine Receptor Binding and Tricyclic Antidepressant Treatment.- 6 Endogenous Ligands for Psychotropic Drug Receptors.- Endogenous Opioids and Motivational Processes: Examination of the Neural Substrates Mediating Opioid-Induced Reward and Aversion.- 7 Biological Markers of Affective Disorders: Impact of Basic Neuroendocrine and Sleep Research.- Sleep-Physiological Characteristics as Potential Biological Markers in Affective Disorders.- Experimental Approaches for Testing the Cholinergic-Noradrenergic Imbalance Hypothesis of Affective Disorders.- Cortisol Response to Corticotropin Releasing Hormone in Dexamethasone-Pretreated Patients with Depression.- Differential Effects and Receptors of Corticosteroids in the Brain: Implications for Psychopathophysiology.- Neuropeptides and Affective Disorder.- Molecular Mechanisms Controlling Proopiomelanocortin Gene Expression.- 8 ?-Adrenoreceptors in Depression and for Antidepressant Effect.- Antidepressant Drugs Given Repeatedly and ?1-Adrenoceptors.- The Effect of Phenylethanolamine-N-Methyltransferase Inhibitor on Locomotor Activity in Rats: The Role of Central ?2-Adrenoceptor and PNMT Activity.- Neuroendocrine Studies of ?2-Adrenoceptor Function and the Mechanism of Action of Antidepressant Drugs.- Levoprotiline: Clinical Therapeutic Efficacy and Tolerability.- ?2-Adrenoceptor Interaction with Opiate Receptors.- Influence of Psychotropic Drugs on Pituitary Hormone Secretion with Special Reference to Norepinephrine Reuptake Inhibition.- 9 The Thyroid Axis in Basic and Clinical Research.- The TRH Test in Psychiatric Disorders.- The Blunted TSH Response to TRH — What Does it Tell Us? Biological Monitoring During Psychopharmacological Treatment.- Alcoholism and the Thyroid Axis.- Marginal Hypothyroidism in Mental Illness: Preliminary Assessments of Prevalence and Significance.- Antithyroid Antibodies: Behavioral Significance.- The Simultaneous Use of Four Releasing Factors: Theoretical and Practical Issues.- 10 PET Imaging in Neurosciences and Psychiatry.- Strategies for In Vivo Quantification of Human Neuroreceptors by Positron Emission Tomography.- Positron Emission Tomography with [18F]Deoxyglucose and Topographic EEG in Schizophrenia.- PET Imaging of D2 Receptors in the Living Baboon and Human Brain in Normal and Pathological Conditions Using [76Br]Bromolisuride.- Dopamine Metabolism in Brain Studied with PET.- 11 The Brain-Immune System Interactions.- Activation of Human Monocytes by the Neuropeptide Substance P and by Immune Interferon-?: Evidence of Different Mechanisms.- Neuroimmunomodulation: Electrophysiological Patterns in Brain During the Course of Immune Responses.- Sympathetic Noradrenergic Neural Contacts with Lymphocytes and Macrophages in the Splenic White Pulp of the Rat: Site of Possible Bidirectional Communication and Local Regulation Between the Nervous and Immune Systems.- 12 Neuropeptides: Basic Research.- Gene Expression of Opioid Peptides is Regulated by Electrical Activity.- Biosynthesis of Opioid Peptides.- Modulation of Energy Metabolism by Vasoactive Intestinal Peptide, Adenosine, and K+ in the Cerebral Cortex: Focus on the Cellular Level.- How Neuropeptides Alter Neuronal Excitability.- 13 Clinical Aspects of Neuropeptide Research.- Corticotropin Releasing Factor, the Amygdaloid Complex, and Depression: A Hypothetical Interrelationship.- Clinical Aspects of Neuropeptide Research.- Thyroid Axis Stimulation Tests in Psychiatry.- Corticotropin-Releasing Hormone and the Proopiomelanocortin-Derived Peptides in Depression.- Alterations in Neuropeptide Systems in Alzheimer’s Disease.- Endocrine Response to Tricyclic Antidepressants and Peptides in Depression with Special Regard to Growth Hormone Secretion.- 14 Postmarketing Surveillance of Psychotropic Drugs.- Relative Toxicity of Antidepressants Using Reports Independent of Observer Bias.- Assessment of Drug Utilization and Adverse Drug Reactions in the Federal Republic of Germany.- Drug Surveillance in Psychiatric Patients in the Federal Republic of Germany.- Surveillance of Toxicity of Antidepressants.- A General Perspective of Post-Marketing Surveillance.- Surveillance of Adverse Drug Reactions in the United States.- 15 Pharmacological Aspects of Sleep and Sleep Disorders.- Sleep and Sleep Deprivation Studies in Patients with Premenstrual Depression.- Epidemiological Aspects of Insomnia Research.- Antidepressant Medication and Total Sleep Deprivation in Depressives.- Pharmacology of New Sleep-Improving Drugs.- 16 Drug Effects and Morphological Investigations in Human Postmortem Tissue.- Neurotransmitter Function in Post-Mortem Human Brain: An Overview.- Modulation of Cholinergic Activity in Alzheimer Brains by Potential Drugs.- Reduced Stimulated Adenylate Cyclase Activity in Postmortem Hippocampus of Demented Patients.- Molecular Neuropathology: The Study of Transmitter and Receptor Expression in Human Postmortem Materials by In Situ Hybridization and Receptor Autoradiography.- Further Cytoarchitectonic and Quantitative Studies in the Entorhinal Region of Schizophrenics and Normal Controls by Means of a Modified Nissl Technique.- The Dopaminergic and Glutamatergic Systems in Schizophrenia.- 17 AIDS.- Peptide Intervention in Neuronal Death Caused by the HIV External Envelope Protein: Clinical Implications.- AIDS as a Neuropeptide Disorder: Does HIV Bind to a VIP Receptor?.- Neuropsychiatry of AIDS: Clinical Presentation and Treatment Research.- Psychiatric Symptoms and Neuropsychological Deficits in HIV Infection.