Neuromodulation: The Biochemical Control of Neuronal Excitability

ISBN-13: 9780195040975 / Angielski / Twarda / 1986 / 304 str.

Leonard K. Kaczmarek; Irwin B. Levitan; Leonard K. Kaczmarek

Opis

This volume provides an introduction to the general principles of neuromodulation--the key neurobiological process for understanding how the brain works. Emphasizing ion channels and biochemical mechanisms of protein phosphorylation, the book shows how neurons regulate their intracellular calcium concentration by modulating the activity of certain ion channels. It goes on to explain the function of intracellular calcium and describes some fascinating neuromodulatory phenomena in the mammalian brain that have long awaited the kind of mechanistic investigations possible in simpler systems. Bridging the gap between neurochemistry and neurophysiology, the authors make complex concepts and research approaches comprehensible to scientists in either field.

Recenzje

The first chapter of [this book] is devoted to a definition and description of what is meant by the term neuromodulation: "The ability of neurons to alter their electrical properties in response to intracellular changes resulting from synaptic or hormonal stimulation." In the opinion of the reviewer this is a very good restriction, as it appears that this field of cellular neurobiology shows exciting developments....A very good book for general neurobiologists to get quickly acquainted with the newly emerging insights into the mechanisms which neurons use, to change their excitability level. In addition it provides the specialist with an opportunity to broaden his outlook in the field of neurobiology.