Neuroinflammation -- From Bench to Bedside

ISBN-13: 9783662050750 / Angielski / Miękka / 2012 / 238 str.

H. Kettenmann; G. Burton; U. Moenning

Opis

Inflammatory processes have been implicated in the pathophysiology of a variety of neurodegenerative diseases such as Alzheimer's disease, stroke and mUltiple sclerosis. It is now widely accepted that the brain, considered to be an "immunologically privileged" organ, can exhibit immune and autoimmune responses, and it is these responses that may in fact be responsible for many neural pathologies. The participants of the workshop VI Preface Research over the past decade has demonstrated the pivotal role of the microglia in the neuroinflammatory process, and more recent work in the field of chemokines has firmly established their important role in the pathogenesis of inflammatory disease states. Inevitably with the wealth of research being conducted in the field of neuroinflammation comes the hope of identifying novel targets for therapeutic intervention in the inflammatory process which may im- pact on neurodegenerative diseases. The meeting "Neuroinflammation - From Bench to Bedside" aimed to cover the whole spectrum of research currently being pursued in this exciting field, literally taking the participants from the bench - study- ing the importance of the microglia in the inflammatory process and the involvement, in particular, of the rapidly expanding chemokine family in the pathophysiology of neurodegenerative diseases - to the bedside - and the possibilities for novel treatment of disorders as di- verse as multiple sclerosis, Alzheimer's disease, stroke and variant Creutzfeldt-Jakob disease (vCJD).

Spis treści

1 Cellular Components of Neuroinflammation — An Introduction.- 2 Microglia and the Response to Brain Injury.- 3 Elucidating Molecular Mechanisms of Alzheimer’s Disease in Microglial Cultures.- 4 Neuronal SLC (CCL21) Expression: Implications for Neuron—Microglial Signaling System.- 5 Cytokine-Mediated Inflammation and Other Actions in the Central Nervous System.- 6 BSE, Scrapie, and vCJD: Infectious Neurodegenerative Diseases.- 7 Activated Microglia in Alzheimer’s Disease and Stroke.- 8 Inflammation in Stroke — A Potential Target for Neuroprotection?.- 9 Neuroinflammation in Alzheimer’s Disease: Potential Targets for Disease-Modifying Drugs.- 10 The Concept of In Vivo Imaging of Neuroinflammation with [11C](R)-PK11195 PET.- 11 Chemokine Receptors on Mononuclear Phagocytes in the Central Nervous System of Patients with Multiple Sclerosis.- 12 The Role of Apoptosis in Neuroinflammation.- Previous Volumes Published in This Series.

Blurb

Recent work has implicated inflammatory processes in the pathophysiology of a variety of neurodegenerative diseases such as Alzheimer's disease, stroke and multiple sclerosis. In this book leading experts in the field discuss molecular, in vivo and clinical aspects of neuroinflammation. It is hoped, with the wealth of research being conductied in this area, that novel therapeutic targets will be identified which will allow successful therapeutic intervention in a variety of neurodegenerative diseases.