Neuroimmune Diseases: From Cells to the Living Brain

ISBN-13: 9783030195144 / Angielski / Twarda / 2019 / 827 str.

Mitoma, Hiroshi

Opis

A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases

Spis treści

SECTION I. Fundamental pathogenic actions

1Overview of mechanisms underlying neuroimmune diseases

Korn T (Germany)

2 Roles of interleukines in neurological autoimmunity

            Waisman A( Germany)

3 Roles of regulatory T cells in neurological autoimmunity

            Hafler DA (USA)

4 Immune tolerance triggering neurological autoimmunity

            Prabhaker BS (USA)

5 Disruption of blood-brain barrier and blood-nerve barrier: a key step in development of immune-mediated neurological diseases

            Varatharaj A (UK)

6 Pathological mechanisms underlying production of autoantibodies

            Zenker P (Australia)

7 Significance of autoantibodies: cause or result?

            Dalmau J (USA), Lanchaster E (USA)

8 Multiple actions of microglia

            Kettenmann H (Germany)

9 Autoimmune astropathy

            Bradl M (Australlia)

10 Genetic factors indicating susceptibility to neurological diseases

            Baranzini SE (USA)

 

SECTION II. Clinical immunology: Pathogenesis, updated diagnostic criteria and novel therapeutic strategies

1 CNS neuroimmune diseases

11 General principles of immunotherapy

            Vincent A (UK)

12 Multiple sclerosis

            Brownlee WJ (UK)

13 Neuromyelitis optica: Diagnosis and therapies

            Biousse V (USA)

14 Atypical inflammatory demyelinating syndrome

            Hardy TA (Australia)

15 Central nervous system vasculitis

            Benseler SM (Canada)

16 Neuro-Beçhet and Sjőgren disease

            Al-Araji A (UK)

17 Immune-mediated cortical encephalopathy (Limbic encephalitis)

            Graus F (Spain)

18 Immune-mediated cerebellar ataxias

            Hadjivassiliou M (UK)

19 Stiff-Person syndrome

            Balint B (UK)

2 Peripheral neuroimmune diseases

20 Guillain-Barré syndrome

            Goodfellow JA (UK)

21 Chronic inflammatory demyelinating polyneuropathy: Diagnosis and therapy

            Said G (France)

22 Immune-mediated disorders of neuro-muscular junctions

            Gilhus NE (Norway)

23 Myositis

            Oldroyd A (UK)

3 Systemic neuroimmune diseases

24 Infection-related immune diseases

            Hadjivassiliou M (UK)

25 Paraneoplastic neurological syndromes; Diagnosis and Therapies

            Honnorat J (France)

O autorze

Hiroshi Mitoma is Neurologist and Neurophysiologist , Professor and Chairman, Medical Education Promotion Center and Department Medical Education at Tokyo Medical University. 

Mario Manto is Neurologist, Head of the Department of Neurology at the CHU-Charleroi, Professor of Neuroanatomy and Neurological Semiology at the University of Mons. He is also teaching Pathophysiology of the Nervous System. He is the Founding Editor of The Cerebellum, Cerebellum and Ataxias and has written or edited 10 books.