Neuroglia in the Aging Brain

ISBN-13: 9780896035942 / Angielski / Twarda / 2001 / 513 str.

Jean S. de Vellis

Opis

A distinguished panel of internationally recognized neuroscientists comprehensively review the involvement of and changes in glial cells both during the normal aging process and in the major disorders of old age. Topics range from the cellular and molecular changes that occur with aging-especially aging-associated activation of astrocytes and microglia and its relation to neuronal injury and repair-to neuron-glia intercommunication. The contributors show how glial signals may be modulated by hormones, growth factors, neurotransmitters, intracellular metabolism, and intercellular exchanges, as well as by aging of the blood-brain barrier.

Recenzje

Foreword by Paola S. Timiras, md, phd, University of California at Berkeley, Berkeley, CA

Overall, this carefully edited book organized its contents with a shrewd mind to bring out importance of glial cell function in the CNS vis-a-vis its functional unit, the neurons...This book with helpful diagrams and illustrations, and with excellent coverage of literature is not only useful for the beginners in neuroscience, but is an excellent reference material for gerontologists and researchers in neurological disorders. - Journal of Chemical Neuroanatomy

Spis treści

Part I. Cellular and Molecular Changes of Aged and Reactive Astrocytes Neuromorphological Changes in Neuronal and Neuroglial Populations of the Cerebral Cortex in the Aging Rat: Neurochemical Correlations Maria Angeles Peinado, Manuel Martinez, Maria Jesus Ramirez, Adoracion Quesada, Juan Angel Pedrosa, Concepcion Iribar, and Jose Maria Peinado Diversity in Reactive Astrocytes Sudarshan K. Malhotra and Theodor K. Shnitka Astrocytic Reaction After Traumatic Brain Injury Jesús Boya, J. L. Calvo, Angel López-Carbonell, and José E. García-Mauriño Part II. Neuron-Glia Intercommunication Astrocytes In Situ Exhibit Functional Neurotransmitter Receptors Marilee K. Shelton and Ken D. McCarthy Glia and Extracellular Space Diffusion Parameters in the Injured and Aging Brain Eva Syková Intercellular Diffusional Coupling between Glial Cells in Slices from the Striatum Brigitte Hamon, Jacques Glowinski, and Christian Giaume Glial Cell Involvement in Brain Repair and the Effects of Aging Elizabeth A. Howes and Peter J. S. Smith ATP Signaling in Schwann Cells Thierry Amédée, Aurore Colomar, and Jonathan A. Coles Part III. Neurotrophins, Growth Factors, and Neurohormones in Aging and Regeneration Gliosis Growth Factors in the Adult and Aging Rat Brain Gérard Labourdette and Françoise Eclancher Role of Fibroblast Growth Factor-2 in Astrogliosis John F. Reilly Trophins as Mediators of Astrocyte Effects in the Aging and Regenerating Brain Judith Lackland and Cheryl F. Dreyfus Responses in the Basal Forebrain Cholinergic System to Aging Zezong Gu and J. Regino Perez-Polo Effects of Estrogens and Thyroid Hormone on Development and Aging of Astrocytes and Oligodendrocytes Kevin Higashigawa, Alisa Seo, Nayan Sheth, Giorgios Tsianos, Hogan Shy, LathaMalaiyandi, and Paola S. Timiras Part IV. Metabolic Changes Neurotoxic Injury and Astrocytes Michael Aschner and Richard M. LoPachin Ammonium Ion Transport in Astrocytes: Functional Implications Neville Brookes Part V. Astrocytes and the Blood-Brain Barrier in Aging Molecular Anatomy of the Blood-Brain Barrier in Development and Aging Dorothee Krause, Pedro M. Faustmann, and Rolf Dermietzel The Blood-Brain Barrier in the Aging Brain Gesa Rascher and Hartwig Wolburg Astrocytes and Barrier-provided Microvasculature in the Developing Brain Luisa Roncali Part VI. Astrocytes in Neurodegenerative Diseases Microglial and Astrocytic Reactions in Alzheimer's Disease Douglas G. Walker and Thomas G. Beach Activated Neuroglia in Alzheimer's Disease Kurt R. Brunden and Robert C. A. Frederickson Reactive Astroglia in the Ataxic Form of Creutzfeldt-Jakob Disease: Cytology and Organization in the Cerebellar Cortex Miguel Lafarga, Nuria T. Villagra, and Maria T. Berciano Ischemic Injury, Astrocytes, and the Aging Brain Robert Fern Glial-Neuronal Interactions during Oxidative Stress: Implications for Parkinson's Disease Catherine Mytilineou Astrocytic Changes Associated with Epileptic Seizures Angélique Bordey and Harald Sontheimer Synaptic and Neuroglial Pathobiology in Acute and Chronic Neurological Disorders Lee J. Martin Astrocytes and Ammonia in Hepatic Encephalopathy Michael D. Norenberg

Blurb

With the proportion of the aged in the population rapidly increasing, especially those 80 and beyond, it has become imperative to understand not only how to prevent and treat the disabilities and diseases of old age, and to prolong and improve functional ability. The biology of neuroglia has thus emerged as one of the most exciting research areas in the neurosciences. In Neuroglia in the Aging Brain, Jean de Vellis and a distinguished panel of internationally recognized neuroscientists comprehensively review the involvement of and changes in glial cells both during the normal aging process and in the major disorders of old age. Topics range from the cellular and molecular changes that occur with aging-especially aging-associated gliosis in astrocytes and its relation to neuronal injury and repair-to neuron-glia intercommunication. The contributors show how glial signals may be modulated by hormones, growth factors, neurotransmitters, intracellular metabolism, and intercellular exchanges, as well as by aging of the blood-brain barrier. Also discussed is the role of the neuroglia, especially of the astrocytes and microglia, in the etiology of several neurodegenerative diseases, as well as the possibilities for therapeutic interventions in glial responses, and indirectly on neurons.
Illuminating and multidisciplinary, Neuroglia in the Aging Brain provides today's neuroscientists and neuropathologists with powerful new insights into how glial cells are involved in the pathogenesis of major aging disorders and how they may be used therapeutically to encourage neuronal self-renewal.