Neurobiology and Clinical Aspects of the Outer Retina

ISBN-13: 9789401042376 / Angielski / Miękka / 2012 / 501 str.

M. B. Djamgoz; S. Archer; S. Vallerga

Opis

This comprehensive work reviews the neurobiological organisation of the vertebrate outer retina with an emphasis on mammalian systems. An international team of contributors discuss the ways in which outer retinal neurones and their interconnections are disrupted in clinical conditions.

Recenzje

A volume reviewing what we know about the outer retina is welcome, and the present volume is superb...brings the whole subject up to date and is an essential read for anyone in this field. I recommend it highly - Trends in Neuroscience

Spis treści

Development and morphological organization of photoreceptors. Cell biology and metabolic activity of photoreceptor cells: light-evoked and circadian regulation. Determinants of visual pigment spectral location and photoreceptor cell spectral sensitivity. Molecular biology of visual pigment molecules. Phototransduction, excitation and adaptation. Photoreceptor synaptic output: neurotransmitter release and photoreceptor coupling. Photoreceptor-horizontal cell connectivity: synaptic transmission and neuromodulation. Horizontal cell coupling and its regulation. Cross-talk between cones and in horizontal cells through the feedback circuit. Neurotransmitter release from horizontal cells. The organization of photoreceptor to bipolar synapses in the outer plexiform layer. Photoreceptor-bipolar cell transmission. Functional architecture of mammalian outer retina and bipolar cells. Neurotransmitter release from bipolar cells. Interplexiform cell connectivity in the outer retina. The involvement of Mueller cells in the outer retina. Clinical aspects: Outer retinal dystrophies. Clinical aspect: Retinitis pigmentosa. Clinical aspects: Paraneoplastic retinopathy. Clinical aspects: Parkinson's disease.