Neuro-Immune Interactions in Neurologic and Psychiatric Disorders

ISBN-13: 9783642640650 / Angielski / Miękka / 2011 / 204 str.

P. Patterson; C. Kordon; Y. Christen

Opis

The idea that the brain is an "immune-privileged site" has perhaps served to slow our realization that the intact brain can generate its own inflammatory reactions. These responses can be to peripheral infection, or they can arise from local, internal causes, for instance as a response to stress or to the se vere changes in neuronal activity in seizure or the loss of oxygen in stroke. We are also becoming increasingly aware of the contribution of local inflam matory reactions to certain neurodegenerative diseases such as Alzheimer's In fact, evidence is accumulating that inflammatory processes disease (AD). contribute to the progression of AD, suggesting the possibility of using cur rently available or novel anti-inflammatory agents to interfere with this terri ble disease. Correlations are also being made between inflammatory signs and mental illness, which is a new frontier of research. This book presents the current state of knowledge in a variety of areas relevant to neuro-immune interactions, with particular attention to AD."

Spis treści

Organization of inflammatory processes in Alzheimers disease.-Glial cytokines in neurodegenerative conditions.-Contributions of the glial injury response to the multifactorial pathogenesis of Alzheimer's Disease.-Cytokine communication between neurons and glia and the pathogenesis of Alzheimer's disease.-Glial hyperactivity during aging as a neuroinflammatory process.-Mechanistic and metaphorical connections between NF-kB and the secreted Alzheimer's ß-amyloid precursor protein.-Pathological and biochemical studies of chronic neuroinflammation may lead to therapies for Alzheimer's disease.-Serotonine-immune interactions in major depression.-Responses in the Raphe-hippocampal serotonergic system during peripheral inflammation: Putative role in sickness behaviour.-Neuronal control of the immune response in the central nervous system: From pathogenesis to therapy.- And other contributions

Blurb

This book arrives at the moment when the role of inflammatory processes in neurodegenerative disease, mental illness, and injury is starting to become more widely appreciated. As summarized in these chapters from some of the major laboratories in the field, not only can the brain interact actively with the immune system, but it can generate its own inflammatory responses to stress, certain diseases, and other insults. The contribution of cytokines and other inflammatory molecules to Alzheimer's disease is highlighted here, as is the key importance of the brains's own inflammatory cells, the microglia. Such studies in cell culture and in animal models clearly have the potential to influence clinical practice. The two-way communication between the brain and the immune system is emphasized by experiments showing that infection in peripheral tissues can cause dramatic changes in behavior of animals, while behavioral states such as severe depression can induce marked changes in immune function. These molecular and anatomical bases for such interactions are becoming understood, which will ultimately have therapeutic implications.