Neuraxial Therapeutics: A Comprehensive Guide

ISBN-13: 9783031395574 / Angielski

Tony Yaksh; Salim Hayek

Spis treści

History and Evolution of Intrathecal Drug Delivery

Intraspinal Anatomy: Considerations in Intrathecal Drug Delivery

Spinal Target Receptors in Intrathecal Drug Delivery

Mechanisms of Action of Intrathecally Administered Agents

Physicochemical Properties and Compounding of Intrathecally Administered Agents

Cerebrospinal Fluid Flow Dynamics

Uptake and Distribution of Intrathecally Administered Agents

Animal Models of Intrathecal Drug Delivery: Clinical Correlates

Intrathecal Drug Delivery for Pain: Medical Considerations

Intrathecal Drug Delivery for Pain: Psychological Considerations

Intrathecal trialing Techniques for Pain Indications

Catheter Localization and Programming Parameters for Pain

Maintenance and Troubleshooting of Intrathecal Therapy for Pain

Intrathecal Agents: Choices for Pain

Intrathecal Therapy for Cancer Pain: Best Practices

Intrathecal Therapy

for Non-Cancer Pain: Best Practices

Managing Complications of Intrathecal Therapy for Pain

Assessing Patients with Movement Disorders for Intrathecal Therapy

Trialing Techniques for Spasticity

Catheter Localization and Programming Parameters for Spasticity

Intrathecal Agents Use for Spasticity

Maintenance and Troubleshooting of Intrathecal Therapy for Spasticity

Managing Complications of Intrathecal Therapy for Spasticity

System Choices

Implantation Techniques

Preoperative Considerations

Managing Surgical Complications

Special Patient Populations (Children, Anticoagulation, Other implanted devices)

Cost Effectiveness of Intrathecal Drug Delivery

Keys to Managing a Successful Targeted Drug Delivery Practice

e-font:minor-latin;mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA">Targeted Drug Delivery: Beyond the Spinal Canal

O autorze

Salim M. Hayek, MD, PhD

University Hospitals of Cleveland

Division of Pain Medicine

Department of Anesthesiology

Cleveland, OH USA

 

Tony L. Yaksh, PhD

University of California, San Diego

Department of Anesthesiology and Pharmacology

La Jolla, CA USA

Blurb

This book is a comprehensive reference of the neuraxial route for the delivery of therapeutics.  It reviews the historical evolution of this approach from its inception in the later 1800's to present day. This amply referenced text covers basic discussions of spinal anatomy, embryogenesis, neuraxial vascularity, cerebrospinal fluid flow dynamics and parenchymal molecule movement. The pharmacokinetic and pharmacodynamic properties of different intrathecal agents are explored in detail with particular reference to clinical correlates  in pain and spasticity. Particular attention is paid to the issues relevant to preclinical models of intrathecal delivery and the assessment of spinal pathologies arising from acute and chronic intrathecal drug delivery. Chapters provide essential discussions of clinical aspects of patient care, including patient evaluation and screening, trialing and device management, troubleshooting problems and addressing complications, best practices, cost-effectiveness and future of the therapy. 

Clinicians and researchers who practice intrathecal therapy and study neuraxial mechanisms will find Neuraxial Therapeutics: A Comprehensive Text, to be an invaluable guide to this treatment modality.