Neural Stem Cells for Brain and Spinal Cord Repair

ISBN-13: 9781588290038 / Angielski / Twarda / 2002 / 434 str.

Tanja Zigova; Evan Y. Snyder; Paul R. Sanberg

Opis

Active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain. They also present strategies that may lead to fruitful clinical applications in the near future. These range from the replacement of degenerated, dysfunctional, or maldeveloped cells to the provision of factors that may protect, correct, recruit, promote self-repair, or mediate the connectivity of host cells.

Recenzje

"The purpose is to address research protocols and possible future applications of neural stem cells in clinical practice. The author has met the objectives. . .Starting from the basic aspects of cell culturing, this book emphasizes the different available research protocols that are currently being used for possible management of neurological degenerative diseases. In addition, molecular mechanisms of interaction are always explained whenever necessary. This book is a perfect purchase for neurologists and neuroscientists. Neurosurgeons with a basic science interest would also find this a useful acquisition."-Doody's Health Sciences Book Review Journal

Spis treści

Part I. Stem Cells for and from the CNS: Their Source and Fundamental Properties Sources of Cells for CNS Therapy Melissa K. Carpenter, Mark Mattson, and Mahendra S. Rao Neural Stem Cells and Their Plasticity Angela Gritti, Angelo Vescovi, and Rossella Galli Identification, Selection, and Use of Adult Human Oligodendrocyte Progenitor Cells Martha Windrem, Neeta Roy, Marta Nunes, and Steven A. Goldman Generation, Characterization, and Transplantation of Immortalized Human Neural Crest Stem Cells Eiji Nakagawa, Kozo Hatori, Atsushi Nagai, Hyun B. Choi, Myung A. Lee, Jung H. Bang, Jean Kim, Jae K. Ryu, Akihiko Ozaki, Min C. Lee, Evan Y. Snyder, and Seung U. Kim The Search for Neural Progenitors in Bone Marrow and Umbilical Cord Blood Shijie Song, Paul Sanberg, and Juan Sanchez-Ramos Part II. In Vitro and/or In Vivo Manipulations of Stem/Progenitor Cells for the CNS Signal Transduction Pathways That Regulate Neural Stem Cell Division and Differentiation Luciano Conti and Elena Cattaneo Neural Stem/Progenitor Cell Clones or 'Neurospheres': A Model for Understanding Neuromorphogenesis Dennis A. Steindler, Bjorn Scheffler, Eric D. Laywell, Oleg N. Suslov, Tong Zheng, Thomas Reiniger, and Valery G. Kukekov Neural Stem Cells and Specification of Cell Fates: Biological and Therapeutical Perspectives Marcel M. Daadi Manipulation of Neural Precursors In Situ: Potential for Brain Self-Repair Sanjay S. P. Magavi and Jeffrey D. Macklis Neural Stem Cells in the Adult Hippocampus Jasodhara Ray and Daniel A. Peterson Part III. Stem/Progenitor Cells in Representative Therapeutic Paradigms for the CNS Global Gene and Cell Replacement Strategies via Stem Cells Kook In Park, James J. Palacino, Roseanne Taylor, Karen S. Aboody, Barbara A. Tate, Vaclav Ourednik, Jitka Ourednik, Mahesh Lachyankar, and Evan Y. Snyder Neural Stem Cells in and from the Spinal Cord, Yang D. Teng, Mary Katherine C. White, Erin Lavik, Shaoxiang Liu, Mahesh Lachyankar, Kook In Park, and Evan Y. Snyder Stem Cells for Spinal Cord Injury, Paul Lu, Evan Y. Snyder, and Mark H. Tuszynski Spinal Ischemia-Induced Paraplegia: A Potential Therapeutical Role of Spinally Grafted Neural Precursors and Human hNT Neurons Martin Marsala, Osamu Kakinohana, Tony L. Yaksh, and Joho Tokumine Utilization of Marrow Stromal Cells for Gene Transfer into the CNS S. Ausim Azizi, Emily J. Schwarz, Darwin Prockop, Guillermo Alexander, Katherine A. Mortati, and Barbara Krynska Preclinical Basis for Use of NT2N Cells in Neural Transplantation Therapy Cesario V. Borlongan and Paul R. Sanberg Index

Blurb

Although neural stem cells (NSCs) have been successfully used in animal models of various neurodegenerative diseases and of brain and spinal cord injuries, their use in studies of nervous system dysfunction is still in its infancy. In Neural Stem Cells for Brain and Spinal Cord Repair, active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain. They also present strategies that may lead to fruitful clinical applications in the near future. These range from the replacement of degenerated, dysfunctional, or maldeveloped cells to the provision of factors (either produced intrinsically by the cells or induced to do so following genetic engineering) that may protect, correct, recruit, promote self-repair, or mediate the connectivity of host cells.
Comprehensive and up-to-date, Neural Stem Cells for Brain and Spinal Cord Repair provides the first systematic overview of the biological properties and functional characteristics of NSCs, as well as outlining of several possible areas of medicine and therapy where these cells may soon prove extremely helpful.