Neural Metabolism in Vivo

ISBN-13: 9781461417873 / Angielski / Twarda / 2012 / 1169 str.

In-Young Choi;Rolf Gruetter

Opis

From the preface: "Neural Metabolism In Vivo aims to provide a comprehensive overview of neurobiology by presenting the basic principles of up-to-date and cutting-edge technology, as well as their application in assessing the functional, morphological and metabolic aspects of the brain. Investigation of neural activity of the living brain via neurovascular coupling using multimodal imaging techniques extended our understanding of fundamental neurophysiological mechanisms, regulation of cerebral blood flow in connection to neural activity and the interplay between neurons, astrocytes and blood vessels. Constant delivery of glucose and oxygen for energy metabolism is vital for brain function, and the physiological basis of neural activity can be assessed through measurements of cerebral blood flow and consumption of glucose and oxygen.... This book presents the complex physiological and neurochemical processes of neural metabolism and function in response to various physiological conditions and pharmacological stimulations. Neurochemical detection technologies and quantitative aspects of monitoring cerebral energy substrates and other metabolites in the living brain are described under the "Cerebral metabolism of antioxidants, osmolytes and others in vivo" section. Altogether, the advent of new in vivo tools has transformed neuroscience and neurobiology research, and demands interdisciplinary approaches as each technology could only approximate a very small fraction of the true complexity of the underlying biological processes. However, translational values of the emerging in vivo methods to the application of preclinical to clinical studies cannot be emphasized enough. Thus, it is our hope that advances in our understanding of biochemical, molecular, functional and physiological processes of the brain could eventually help people with neurological problems, which are still dominated by the unknowns." -- In-Young Choi and Rolf Gruetter

Recenzje

"This is a good textbook concerning the NMR, rms, and brain metabolites. ... I recommend this book for biochemists, neurologists, and physiologists with interests in the brain metabolic disorders of acetate, glutamate, aspartate, GABA, creatine, creatine kinases, and other isoenzymes. ... This is a good book also for imagers and others interested in brain pathology correlation." (Joseph J. Grenier, Amazon.com, May, 2015)

Spis treści

Non-invasive methods for neural metabolism.- In vivo assessment of neural activity via neurovascular coupling.- Cerebral energy metabolism and substrates in vivo.- In vivo assessment of metabolic compartmentation between neurons and glia.- Cerebral metabolism of antioxidants, osmolytes and others in vivo.

Blurb

Neural Metabolism In Vivo strives to offer a comprehensive and fundamental overview of cerebral metabolism by presenting leading-edge in vivo multimodal technology and its application in assessing neural activity, energy metabolism and neurotransmission in the living brain.  The recent advances in our current understanding of the complex and dynamic physiological and neurochemical processes of neural function and metabolism are indebted to a variety of powerful techniques, namely nuclear magnetic resonance, positron emission tomography, radiotracer imaging, optical imaging and micro-dialysis.  With the advent of these in vivo techniques, the collective and devoted efforts of neuroscientists and bioengineers made the brain readily assessable to demystify its complexity.  Specific topics of this volume include energy metabolism specific to the brain from the in vivo assessment of neural activity via neurovascular coupling and glucose uptake, as well as the accompanying consumption of various cerebral energy substrates to metabolic compartmentation and interaction between neurons and astrocytes. This exciting compilation of 41 chapters across two volumes is the result of the dedicated efforts of 99 renowned experts in neurobiology.