Neural Crest Cells: Evolution, Development and Disease

ISBN-13: 9780124017306 / Angielski / Twarda / 2013 / 488 str.

Paul Trainor

Opis

Neural Crest Cells: Evolution, Development and Disease summarizes discoveries of historical significance and provides in-depth, current analyses of the evolution of neural crest cells, their contribution to embryo development, and their roles in disease. In addition, prospects for tissue engineering, repair and regeneration are covered, offering a timely synthesis of the current knowledge in neural crest cell research. A comprehensive resource on neural crest cells for researchers studying cell biology, developmental biology, stem cells and neurobiology, Neural Crest Cells: Evolution, Development and Disease provides foundational information needed for students, practicing physicians and dentists treating patients with craniofacial defects.

• BMA Medical Book Awards 2014 - Highly Commended, Basic and Clinical Sciences,2014, British Medical Association
• Provides timely, comprehensive synthesis of the current knowledge of neural crest cells
• Covers the evolution and development of neural crest cells
• Includes content on applications for tissue engineering, repair and regeneration

Recenzje

"This text is a tour de force in its field and is of significance to embryologists, craniofacial biologists, geneticists, syndromologists and oral and maxillofacial surgeons for its concepts and innovations in this rapidly expanding field. The quality of production from Academic Press is superb, providing a landmark reference work for those in the forefront of craniofacial research and regenerative surgical therapy." --British Dental Journal, May 23, 2014

Spis treści

Part 1: Neural Crest Cell Evolution and Development

Ch 1. The Evolution of Neural Crest Cells;Ch 2. Neural Crest Cell Induction and Specification - Signals and Switches; Ch 3. Neural Crest Cell Delamination - Cell Adhesion and Polarity; Ch 4. Neural Crest Cell Migration - Guidance and Pathways; Ch 5. Epigenetic Regulation of Neural Crest Cells; Ch 6. Neural Crest Stem and Progenitor Cells; Ch 7. Neural Crest Cells and Tissue Interactions - Species specificity, growth, shape, patterning and programming

Part II: Neural Crest Cell Differentiation and Disease

Ch 8. Neural Crest Cells in Cranioskeletal Development; Ch 9. Neural Crest Cells and Placode Interactions in Cranial PNS Development; Ch 10. Neural Crest Cells in Ear Development; Ch 11. Neural Crest Cells in Eye Development; Ch 12. Neural Crest Cells in Heart Development; Ch 13. Neural Crest Cells in Enteric Nervous System Formation; Ch 14. Neural Cells and Trunk PNS Formation; Ch 15. Neural Crest Cells in Melanocyte Development and Pigmentation; Ch 16. Neural Crest Cells in Vasculogenesis; Ch 17. Neural Crest Cells as a Model for Metastasis and Cancer

Part III: Tissue Engineering and Repair

Ch 18. Neurocristopathies; Ch 19. Neural Crest Cells in Human Embryos - implications for iPS; Ch 20. Neural Crest Stem Cells in Tissue Regeneration and Repair; Ch 21. Neural crest cells in tooth development and repair; Ch 22. Disease Specific iPS Neural Crest Cells

O autorze

Paul Trainor, PhD is an Investigator at the Stowers Institute for Medical Research in Kansas City, MO USA with over 20 years of experience working in the fields of developmental biology, neurobiology and craniofacial morphogenesis. He received his PhD from the University of Sydney, Australia under the tutelage of Dr Patrick Tam before undertaking post-doctoral training with Dr Robb Krumlauf at the National Institute for Medical Research in London, England. The current emphasis of Dr Trainor's research centres on the role of neural crest cells in craniofacial evolution, development and disease. He seeks to understand the mechanisms that regulate neural crest cell patterning and apply this basic knowledge to decipher the etiology and pathogenesis of birth defects and potentially develop therapeutic avenues for their prevention. His laboratory studies neurocristopathies (disorders of neural crest cell development) such as Treacher Collins syndrome, Holoprosencephaly and Syngnathia as well as other neurocristopathy disorders such as Hirschsprung disease. Dr Trainor is currently vice-present of the Society for Craniofacial Genetics and Development.