Neonatal Immunity

ISBN-13: 9781588293190 / Angielski / Twarda / 2004 / 389 str.

Constantin Bona; Constantin A. Bona

Opis

A critical review of the classic, as wells as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by maternal antibodies and how, in certain cases, this can cause transient or life-threatening neonatal autoimmune disease. He also describes the characteristics of neonatal tolerance induced by foreign allo- and self-antigens, which are the basis for understanding impaired infant immune response and which provide a rationale for the development of efficient neonatal vaccines. By making clear the characteristics and differences between the immune system and the immune responses of both newborns and infants, compared to those of adults, Dr. Bona offers insights and challenging hypotheses that promise to help overcome the poor responses of neonates to various antigens.

Recenzje

"...an excellent reference reference for both reviewing the existing literature and for updating our current knowledge and understanding of how the immune system develops during foetal and neonatal life. This text is by far the most comprehensive review to date on neonatal immunity and I strongly recommend it to anyone with interest in the field." -Australian Veterinary Journal

"...an excellent source of both old and cutting-edge information on neonatal immunity." - New England Journal of Medicine

Spis treści

Structure and Function of the Immune System in Vertebrates Ontogeny and the Development of Cells Mediating Innate and Adaptive Immunity Phenotypic Characteristics of Neonatal B Cells Molecular Characteristics of Neonatal B-Cell Repertoire Genetically Programmed Temporal Ordered Activation of Neonatal B-Cell Clones Antibody Response in Fetuses and Newborns Effect of Maternal Antibodies on Neonatal B-Cell Response Neonatal Autoimmune Diseases Caused by Maternal Pathogenic Autoantibodies Phenotypic Characteristics of Neonatal T Cells Expression of MHC Molecules in Neonates. Neonatal Cytokine Network Cell-Mediated Immune Responses in Neonates. Fetal and Neonatal Tolerance Development of Efficient Prophylactic Vaccines and Theracines for Newborns and Infants References Index.

Blurb

New advances in cellular immunology, molecular biology, recombinant DNA and proteins, and the function of cytokines and chemokines have revolutionized the study of neonatal immune responsiveness. In Neonatal Immunity, Constantin Bona, MD, critically reviews the classic, as well as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by maternal antibodies and how, in certain cases, this can cause transient or life-threatening neonatal autoimmune disease. He also describes the characteristics of neonatal tolerance induced by foreign allo- and self-antigens, which are the basis for understanding impaired infant immune response and which provide a rationale for the development of efficient neonatal vaccines. By making clear the characteristics and differences between the immune system and the immune responses of both newborns and infants, compared to those of adults, Dr. Bona offers insights and challenging hypotheses that promise to help overcome the poor responses of neonates to various antigens.
Authoritative and forward-looking, Neonatal Immunity critically reviews what we know of the neonatal immune response today, and how this is dramatically opening new therapeutic horizons in such areas as infant vaccination, stem cells, gene therapy, and transplantation.