Necrotizing Enterocolitis: Pathogenesis, Diagnosis and Treatment

ISBN-13: 9781138343245 / Angielski / Twarda / 2021 / 288 str.

David J. Hackam

Opis

Necrotizing enterocolitis (NEC) was described over 30 years ago, and remains the leading cause of death in premature infants from gastrointestinal disease. It is axiomatic that necrotizing enterocolitis is both a devastatingly serious disease, and also one in which its very underpinnings remain mysterious

Spis treści

List of Contributors. Introduction: Necrotizing Enterocolitis, The Stories of Its Tiny Patients, and the Journey Ahead. Nursing Considerations in Necrotizing Enterocolitis: Management of Infant Stomas. Nursing Considerations in Necrotizing Enterocolitis: Management of Central Venous Catheters. An Updated Overview of the Medical Management of Necrotizing Enterocolitis. Clinical Clues, Biochemical Indices, and Biomarkers: Diagnostic Considerations in Necrotizing Enterocolitis. Imaging Considerations in NEC Diagnosis: Plain Films, Ultrasound, and Everything Else. Spontaneous Intestinal Perforation (SIP) Is Not Necrotizing Enterocolitis but Remains the Major Confounder of NEC Data. International Practice Patterns in NEC Management: North America, Europe, and Australasia. Feeding Strategies in the Patient with Necrotizing Enterocolitis. Surgery for Necrotizing Enterocolitis: Indications, Techniques, and Outcomes. Major Issues Related to Progress in NEC. Probiotics in the Prevention of Necrotizing Enterocolitis. Cardiovascular, Hemodynamic, and Critical Care Considerations in the Patient with Necrotizing Enterocolitis. Neurodevelopmental Considerations in the Patient with Necrotizing Enterocolitis. Lung Disease and Ventilator Strategies in Necrotizing Enterocolitis. Clinical Trials in NEC Research: Advances, Perils, and Pitfalls. Management of Short Bowel Syndrome after Necrotizing Enterocolitis. Necrotizing Enterocolitis in Unusual Cases: Term Infants, Congenital Anomalies, and Comorbidities. Intestinal Transplantation for Necrotizing Enterocolitis. Optical Spectroscopy for the Detection of Necrotizing Enterocolitis. Anesthetic Management of the Neonate with Necrotizing Enterocolitis. Novel and Alternative Techniques in Surgery for Necrotizing Enterocolitis. Supporting NEC Risk Awareness with Bedside Tools Like GutCheckNEC. Health Economics and Care Delivery Issues in Necrotizing Enterocolitis. Quality Improvement and Necrotizing Enterocolitis. Implementation Strategies for Quality Improvement to Avoid Necrotizing Enterocolitis. Clinical Outcomes in Children with NEC. Contextualizing Necrotizing Enterocolitis within Health Disparities Research. Ethical Issues in the Care of Children with Necrotizing Enterocolitis. Family Perspective of Necrotizing Enterocolitis. The Role of Toll-Like Receptor Signaling in the Pathogenesis of NEC. The Role of Growth Factor Signaling in the Development and Treatment of Necrotizing Enterocolitis. The Role of Platelet-Activating Factor in the Pathogenesis of Necrotizing Enterocolitis. The Role of Vascular Development in the Pathogenesis of Necrotizing Enterocolitis. Bile Acids in the Pathogenesis of Necrotizing Enterocolitis. Bacterial Communities in the Pathogenesis of Necrotizing Enterocolitis. The Importance of Immune Cells in the Pathogenesis of NEC. The Role of Nitric Oxide Signaling in the Pathogenesis of Necrotizing Enterocolitis.. The Silver Lining: The Small Intestinal Epithelial Barrier and Its Role in Necrotizing Enterocolitis. Innate and Adaptive Immune Dysfunction and Necrotizing Enterocolitis. Intestinal Immune Adaptation and Necrotizing Enterocolitis. Advancements in Research on Necrotizing Enterocolitis Pathogenesis and Prevention Using Pigs. Small Animal Models for the Study of Necrotizing Enterocolitis and "NEC-in-a-Dish". Nutritional Considerations in Necrotizing Enterocolitis. The Paneth Cell and Its Role in the Development of NEC. Human Donor Milk and Necrotizing Enterocolitis. The Genetic Basis of NEC Susceptibility. Anemia as a Modifiable Risk Factor for NEC. Lipids and Lipid Metabolism in Postnatal Gut Development and Risk of Intestinal Injury. Machine Learning in Necrotizing Enterocolitis: Challenges and Opportunities. Necrotizing Enterocolitis Risk from a Maternal-Fetal Medicine Perspective. Future Directions and Research Opportunities in NEC: The Top Ten Unanswered Questions and Top Five Areas of Research Focus. Index.

O autorze

David J. Hackam, MD, PhD, FACS.
Pediatric Surgeon-in-Chief and Co-Director, The Johns Hopkins Children’s Center
Garrett Professor and Chief of Pediatric Surgery,
Professor of Surgery, Pediatrics, Cell Biology, and Genetic Medicine
Johns Hopkins University School of Medicine
Baltimore, Maryland , USA