Natural Products: Drug Discovery and Therapeutic Medicine

ISBN-13: 9781588293831 / Angielski / Twarda / 2005 / 386 str.

Lixin Zhang; Lixin Zhang; Arnold L. Demain

Opis

A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.

Recenzje

From the reviews:

"Natural Products, Drug Discovery and Therapeutic Medicine timely shares the experience of renowned scientist from academy and industry working in the field. ... a very comprehensive tool that will help everybody interested in the discovery of natural products. I highly recommend this book for those who want to understand the potential of drug development from natural products in the light of modern knowledge and technology as well as for individuals who want to understand history of pass successes in drug discovery from natural products." (Sonia Mesia-Vela, Phytomedicine, Vol. 13, 2006)

Spis treści

Part I. Fundamental Issues Related to Natural Product-Based Drug Delivery Natural Products and Drug Discovery Arnold L. Demain and Lixin Zhang Part II. Strategies Integrated Approaches for Discovering Novel Drugs From Microbial Natural Products Lixin Zhang Automated Analyses of HPLC Profiles of Microbial Extracts: A New Tool for Drug Discovery Screening José R. Tormo and Juan B. García Manipulating Microbial Metabolites for Drug Discovery and Production C. Richard Hutchinson Improving Drug Discovery From Microorganisms Chris M. Farnet and Emmanuel Zazopoulos Developments in Strain Improvement Technology: Evolutionary Engineering of Industrial Microorganisms Through Gene, Pathway, and Genome Shuffling Stephen B. del Cardayré Part III. Specific Groups of Drugs The Discovery of Anticancer Drugs From Natural Sources David J. Newman and Gordon M. Cragg Case Studies in Natural-Product Optimization: Novel Antitumor Agents Derived From Taxus brevifolia and Catharanthus roseus Jian Hong and Shu-Hui Chen Terpenoids As Therapeutic Drugs and Pharmaceutical Agents Guangyi Wang, Weiping Tang, and Robert R. Bidigare Challenges and Opportunities in the Chinese Herbal Drug Industry Wei Jia and Lixin Zhang Arsenic Trioxide and Leukemia: From Bedside to Bench Guo-Qiang Chen, Qiong Wang, Hua Yan, and Zhu Chen Part IV. Microbial Diversity New Methods to Access Microbial Diversity for Small Molecule Discovery Karsten Zengler, Ashish Paradkar, and Martin Keller Accessing the Genomes of Uncultivated Microbes for Novel Natural Products Asuncion Martinez, Joern Hopke, Ian A. MacNeil, and Marcia S. Osburne Part V. Specific Sources New Natural-Product Diversity From Marine Actinomycetes Paul R. Jensen and WilliamFenical Novel Natural Products From Rainforest Endophytes Gary Strobel, Bryn Daisy, and Uvidelio Castillo Biological, Economic, Ecological, and Legal Aspects of Harvesting Traditional Medicine in Ecuador Alexandra Guevara-Aguirre and Ximena Chiriboga Index

Blurb

Although the natural product drug discovery programs of the large drug companies are now equaled by programs for the high throughput screening of synthetic compounds generated through combinatorial chemistry, natural compounds still hold great promise to overcome such problems as antibiotic resistance, the emergence of new diseases, the failure to conquer old diseases, and the toxicity of some contemporary medical products. In Natural Products: Drug Discovery and Therapeutic Medicine, a panel of recognized experts and leaders in the field discuss the past successes of natural products as medicines and review future possibilities arising from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discovery, to accessing microbial diversity, to investigating specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to exploiting specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
State-of-the-art and forward looking, Natural Products: Drug Discovery and Therapeutic Medicine will inspire industrial and academic researchers, practitioners, and developers to once again explore natural products as key sources for the many new drugs needed to solve still unmet medical needs.