Natural Products Chemistry: Sources, Separations, and Structures

ISBN-13: 9781466567610 / Angielski / Miękka / 2014 / 206 str.

Raymond Cooper; George Nicola

Opis

Compounds isolated from nature have long been known to possess biological profiles and pharmaceutical potential far greater than anything made by man. However, they are notoriously cumbersome to isolate and challenging to synthesize, and the path of natural products to viable drugs is an arduous journey. This book presents a practical guide to gathering, isolating, and discovering new pharmaceuticals from nature. It emphasizes the challenges and advantages of products acquired from nature over traditional compounds such as those arising from combinatorial chemistry.

Spis treści

History of Natural Products. Terrestrial. Marine. Bioprospecting. Biological and Pharmacological Aspects. Fractionation and Isolation. Structure Elucidation. X-ray crystallography. NMR. Mass Spectrometry. Biosynthesis. Chemical Synthesis. Optimization for Mass Production and Manufacturing. Medicinal Applications. Integrating with System Biology. Computational Chemistry. Sustainability. Biopiracy. Environmental Protection. International Treaties. Translation. Curation and Digitization. Intellectual Property. Licensing and Strategy.

O autorze

Drs. Cooper and Nicola were introduced to each other by CRC Press editor Hilary Rowe during a natural products conference. Inspired to pursue his passion for natural products by his former high school chemistry teacher, Dr. Cooper credits his longevity in the field to the great people and teams he has had the good fortune and privilege of working with. He says that one of the most rewarding aspects of his work has been the satisfaction that comes from being part of a team that is able to bring new products of natural product origin to market.