Natural Killer Cells: Basic Science and Clinical Application

ISBN-13: 9780123704542 / Angielski / Twarda / 2009 / 660 str.

Michael T Lotze

Opis

Natural Killer Cells explains the importance of killer cells and how they are produced. It mentions that the most likely explanation for killer cell production is that they serve as a complementary system for T cells as a primary defense against viruses. However, these cells defend against certain viruses only, such as herpes viruses and influenza viruses. The book also explains the primary functions of killer cells, and it discusses how these cells help recognize damaged tissues, limit further damage to tissues, and regenerate damaged tissues. It discusses how these cells mature and develop, and it covers the different isolation, culture, and propagation methods of these cells. Furthermore, it focuses on the different killer cells that are present in various parts of the human body. The book concludes by explaining that natural killer cells are utilized for clinical therapy of malignancies, and that they have led to positive outcomes in the field of biology and medicine.

• Provides a broad, detailed coverage of the biology and interactions of NK cells for students, fellows, scientists, and practitioners
• Includes figures, histologic sections, and illustrations of the ontogeny of NK cells

Spis treści

I. NK BIOLOGY; Developmental Stages and Pathways of NK Cell Maturation; Developmental Origins of Thymus-Derived Natural Killer Cells; Interferon-Producing Killer Dendritic Cells (IKDC); Natural Killer Cells in Cancer; NK Cell Immune Recognition: NKG2D Ligands and Stressed Cells; NK Cell KIR Heterogeneity and Evolution; Signaling Events in Natural Killer Cells; Human Natural Killer Cell Development; II. NK INTERACTIONS WITH OTHER CELLS; Isolation, Culture and Propagation of Natural Killer (NK) Cells; The Localization and Migration of Natural Killer Cells in Health and Disease; Receptors on NK Cells; Development and Testing of NK Cell Lines; NK Cell-derived Cytokines and Delivery; NK Cell Synapses; NK Cells as Recipients of Cytokine Signals; NK Cells and Chemokines; Natural Killer Cytolytic Activity; Illuminating Intranodal Natural Killer Cell Behavior Using Two-Photon Microscopy; Dendritic Cells and NK Cells; NK and NKT cells: The Innate- Adaptive Interface Including Humoral Responses; NK Cell and Endothelial Cell Interactions; NK Cell/Epithelial Interactions; NK Cell-T Cell Interactions; III. NK CELLS IN THE TISSUES; NK Cells and NKT Cells in Cutaneous Disorders; Natural Killer Cells in the Respiratory Tract; Intestinal Natural Killer Cells; Natural Killer Cells in the Liver; Natural Killer Cells in the Spleen and Lymph Node; Natural Killer Cells in the Central Nervous System; NK Cells in the Eye; NK Cells and Reproduction; Identification of Natural Killer Cells in Tissues and Their Isolation; NK Cell Immune Regulation: Coordination of Immune Function in Tissues; IV. NK CELLS IN DISEASE; Natural Killer Cells and Transplantation; Natural Killer Cells and Autoimmunity; Interaction of NK Cells with Bacteria; Natural Killer Cells and Human Immunodeficiency Virus; Cytomegalovirus Infection and NK Cells; Natural Killer Cells in Allergy; Natural Killer Cells in Wound Healing; Natural Killer Cells in Atherosclerosis; Natural Killer Cells in Leukemia; Natural Killer Cells and Allogeneic Hematopoietic Cell Transplantation; Clinical Trials of NK Cells for Cancer; Natural Killer Cells and Hepatitis C Virus Infection; Natural Killer Cells and the Biology of Parasitism; Lymphoproliferative Disorders of Natural Killer Cells; V. SPECIAL TOPICS IN NK BIOLOGY; Natural Killer Cell Induction of Tolerance; Genetic Engineering of Natural Killer Cells; NK Cell-Mediated Target Cell Death; NK-Cell Tracking Using Non-Invasive Imaging Modalities