Nanotherapy for Brain Tumor Drug Delivery

ISBN-13: 9781071610541 / Angielski / Miękka / 2021

Opis

This volume provides a guide on nanoformulations and other drug delivery approaches for both academic and industry scientists. The chapters in this book cover diverse topics and techniques in nanoparticle drug delivery, gene therapy, neurosurgical brain implant, exosomes, MRI-guided focused ultrasound (MRgFUS), and advanced preclinical glioblastoma multiforme animal models. Some chapters discuss state-of-the-art and innovative nanomedicines for glioblastoma, surface-modified nanoparticle drug carriers for brain cancer treatment, focused ultrasound (FUS)-mediated blood-brain barrier disruption for enhanced drug delivery to brain tumors; gene therapy delivery approaches to treat brain cancer, and a liposome-template hydrogel nanoparticles (LHNPs) as a powerful CRISPR/Cas9 delivery vehicle. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. 

Cutting-edge and thorough, Nanotherapy for Brain Tumor Drug Delivery is a valuable resource for the scientific community working on this important therapeutic field, and will help fast-track the clinical translation of revolutionary nanotechnologies for treating brain tumors.    

Spis treści

Series Preface…
Preface…
Table of Contents…
Contributing Authors…

1. Glioblastoma: State of Art of Treatments and Application of Polymeric and Lipidic Nanomedicines
Valeria Sgarbi, Jason T. Duskey, Ilaria Ottonelli, Natalia Oddone, Maria Angela Vandelli, Flavio Forni, Giovanni Tosi, and Barbara Ruozi

2. Passive and Active Targeting of Brain Tumors
Amr Hefnawy and Ibrahim M. El-Sherbiny

3. Strategies to Modulate the Blood Brain Barrier for Directed Brain Tumor Targeting
Paula Schiapparelli, Montserrat Lara-Velazquez, Rawan El-kharboosh, Hao Su, Honggang Cui, and Alfredo Quinones-Hinojosa

4. Drug Delivery Approaches and Imaging Techniques for Brain Tumor
Mark Bell, Christine Pujol Rooks, and Vibhuti Agrahari

5. Surface-Modified Nano-Drug Carriers for Brain Cancer Treatment
Aniket S. Wadajkar, Nina P. Connolly, Christine P. Carney, Pranjali P. Kanvinde, Jeffrey A. Winkles, Graeme F. Woodworth, and Anthony J. Kim

6. Inorganic Nanostructures for Brain Tumor Management
Mohd Imran, Awais Ahmed Abrar Ahmed, Babak Kateb, and Ajeet Kaushik

7. Strategies to Enhance the Distribution of Therapeutic Nanoparticles in the Brain by Convection Enhanced Delivery
Karina Negron, Namir Khalasawi, and Jung Soo Suk

8. Focused Ultrasound-Mediated Blood-Brain Barrier Disruption for Enhanced Drug Delivery to Brain Tumors
Pavlos Anastasiadis, Jeffrey A. Winkles, Anthony J. Kim, and Graeme F. Woodworth

9. Neurosurgical Implant-Based Strategy for Brain Cancer Therapy
Joshua Casaos, Noah Gorelick, and Betty Tyles

10. Liposome-Templated Hydrogel Nanoparticles for Targeted Delivery of CRISPR/Cas9 to Brain Tumors
Zeming Chen, Ann T. Chen, and Jiangbing Zhou

11. Methods to Separate, Characterize, and Encapsulate Drug Molecules into Exosomes for Targeted Delivery and Treatment of Glioblastoma
Yen Nguyen, Sandeep Kaur, Hae Shim, Vaibhav Mundra, and Venkatareddy Nadithe

12. Establishing Orthotopic Xenograft Glioblastoma Models for Use in Preclinical Development
João Basso, José Sereno, Ana Fortuna, Miguel Castelo-Branco, and Carla Vitorino

Subject Index List...