1. Introduction: An Overview of the Anatomy and Physiology of the Brain2. Angiogenesis in brain tumors3. Physiology of the Blood Brain Barrier (BBB) and mechanisms of Transport across the BBB4. Active Targeting Systems (Ligands) / Receptor overexpressed on brain5. Nanotechnology in Brain Targeting6. Polymeric nanoparticles based drug delivery for brain tumors7. Solid lipid nanoparticles (SLN)based drug delivery for brain tumors8. Liposomes based drug delivery for brain tumors9. Dendrimers based drug delivery for brain tumors10. Micelles based drug delivery for brain tumors11. Nanoemulsions based drug delivery for brain tumors12. Nanogel based drug delivery for brain tumors13. Beyond the blood-brain barrier - facing new challenges14. Towards development of neuro-diagnostic nano-imaging platform15. Future prospects of nanoparticles on brain targeted drug delivery