Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes

ISBN-13: 9780128097175 / Angielski / Miękka / 2017 / 552 str.

Vijay Mishra; Prashant Kesharwani; Mohd Cairul Iqbal Mohd Amin

Opis

Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes provides an overview of the important aspects of nanomedicine in order to illustrate how to design and develop novel and effective drug delivery systems using nanotechnology. The book is organized into three sections, beginning with an introduction to nanomedicine and its associated issues. Section two discusses the latest technologies in nanomedicine, while the third section covers future developments and challenges in the field. By focusing on the design, synthesis, and application of a variety of nanocarriers in drug and gene delivery, this book provides pharmaceutical and materials science students, professors, clinical researchers, and industry scientists with a valuable resource aimed at tackling the challenges of delivering drugs and genes in a more targeted manner.

• Explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advances in cutting-edge nanomedical technologies
• Contains contributions from world-renowned experts and researchers working in the area of nanomedicine and drug delivery
• Covers the associated challenges and potential solutions to working with nanotechnology in drug delivery
• Highlights crucial topics, such as biopharmaceutical and toxicity issues, quality by design, drug targeting, and more

Spis treści

Section 1: Introduction and Issues in Nanomedicine1. Nanotechnology in development of nanomedicines2. Concept of enhanced permeability and retention (EPR) effect for drug targeting3. Non-EPR effect for Targeting4. Translational Medicine5. Quality-by-design approach in development of nanocarriers

Section 2: Current Technologies in Nanomedicine6. Liposomes in targeting and delivery of drugs7. Surfactant-based nanocarriers in targeting and delivery of drugs8. Polymeric micelle in targeting and delivery of drugs9. Polymeric nanoparticles in targeting and delivery of drugs10. Solid Lipid Nanoparticles in targeting and delivery of drugs11. Dendrimers in targeting and delivery of drugs12. Carbon nanotubes in targeting and delivery of drugs13. Quantum dots in targeting and delivery of drugs14. Biomaterials in peptides and protein delivery

Section 3 - Future Developments and Challenges in Nanomedicine15. Biopharmaceutical Aspects of Nanomaterials16. Toxicity Issues of Nanocarriers

O autorze

Dr. Vijay Mishra, PhD is an Associate Professor at Department of Pharmaceutics, School of Pharmaceutical Sciences, Lovely Professional University, India. Dr. Mishra earned his doctoral degree in Pharmaceutical Sciences from Department of Pharmaceutical Sciences, Dr. H.S. Gour Central University, Sagar (MP), India. He has been a recipient of several internationally acclaimed fellowships and awards including Graduate Research Fellowship (AICTE, New Delhi), UGC- BSR Senior Research Fellowship (UGC, New Delhi) and International Travel Award/Grant (DBT, New Delhi). He has authored more than 50 international publications in well reputed peer-reviewed journals, book chapters, books and patents (filed). He serves as a reviewer and Editorial board member of various journals of high repute. He is a life member of Indian Science Congress Association, Kolkata, India. His current research interests encompass nanomedicine, cancer, toxicology, surface-engineered dendrimers, carbon nanotubes, quantum dots, gold nanoparticles, siRNA delivery as well as controlled and novel drug delivery systems. Dr Kesharwani has more than 200 international publications in well reputed journals and 13 published books (Elsevier). He is a recipient of several internationally acclaimed awards viz 'Ramanujan Fellowship, DST, India-2017', 'Excellence Research Award 2014', 'Young Innovator Award (Gold medal) 2012', 'International Travel Award/Grant from DST (New Delhi) and INSA (CCSTDS, Chennai) 2012'. He has received an ICMR Senior Research Fellowship (PhD) and AICTE Junior Research Fellowship (M. Pharm.). He has presented many invited talks and oral presentations at prestigious scientific peer-conferences, received international acclaims and awards for research contribution, supervised students/junior researchers and actively participated in outreach and scientific dissemination for the service of wider community. An overarching goal of his current research is the development of nano-engineered drug delivery systems for various diseases, including cancer. Dr. Mohd Cairul Iqbal Mohd Amin is a Professor of Pharmaceutics in the Faculty of Pharmacy, Universiti Kebangsaan Malaysia (UKM) in Kuala Lumpur, Malaysia. He is the youngest professor appointed in the faculty and the only expert in the area of pharmaceutics in UKM. He earned his BSc (Hons) in Pharmacy in 1996 and PhD in 2001 both from the University of Manchester, United Kingdom. He is currently the Head of Drug Delivery and Novel Targeting Research Group in UKM. He also serves as panel expert in nanocellulose for drug delivery for the National Nanotechnology Centre, Ministry of Science, Technology and Innovation, Malaysia. His current research interests encompass responsive-hydrogel biomaterials for oral protein and peptide delivery, cell delivery in tissue engineering and nano drug delivery systems in particular polymeric micellar conjugates for cancer research. Dr. Amin has authored more than 60 publications in high impact factor journals, a number of book chapters, has five patents issued/pending and has routinely consulted in the area of drug delivery and pharmaceutical technology. He has wide expertise in biomaterials, nanomedicine, polymer chemistry, micro- and nanotargeting delivery systems as well as oral and transdermal formulations and delivery systems. Dr. Iyer is the Director of Use-inspired Biomaterials and Integrated Nano Delivery (U-BiND) Systems Laboratory and an Associate Professor with Tenure in the Department of Pharmaceutical Sciences at Wayne State University in Detroit, Michigan, USA. He also serves as a Scientific Member of the Molecular Imaging Program (MIP) at the Barbara Ann Karmanos Cancer Institute in Detroit, Michigan, USA. Dr. Iyer received his PhD in 2008, in Polymer Engineering, under the mentorship of world-renowned scientist and 2016 Nobel Prize in Chemistry Nominee, Prof. Hiroshi Maeda at Sojo University in Kumamoto, Japan. Dr. Iyer was the recipient of the Controlled Release Society's (CRS) T. Nagai Research Achievement Award in 2012. Dr. Iyer completed his postdoctoral training in Cancer Radiology at the University of California, San Francisco (UCSF) in California, USA. In 2018 Dr. Iyer received an Early Career Investigator Award from the US Department of Defense (DoD). Dr. Iyer has authored more than 100 publications in peer reviewed International Journals (H-index:45), and books of high repute. He has more than 200 scientific presentations and invited talks at International Conferences and Workshops. He has five patents issued/pending. His areas of research are broadly focused on designing use-inspired bio- and nano-medical technologies aimed towards clinical translation using biocompatible delivery systems that have enhanced disease targeting with reduced toxicity burden to patients. He has wide expertise in biomaterials and nanomedicine, polymer chemistry and formulation development, drug and gene delivery systems, molecular and functional imaging, micro and nanoparticles for treating diseases such as infection,cancerand age-related dementia. His laboratory is funded by agencies such as National Institutes of Health and the US Department of Defense.