Nanocarrier Systems for Drug Delivery for the Treatment of Asthma

ISBN-13: 9783846532614 / Angielski / Miękka / 256 str.

Abdelbary Elhissi; Kevin Taylor; Waqar Ahmed

Opis

This book presents work on nanocarrier systems for pulmonary drug delivery for use in the treatment of asthma. Using sucrose as a carrier, liposomes were generated or dispersed in situ from proliposomes within the medical nebulisers investigated. The Pari (air-jet) and the Omron (vibrating-mesh) nebulisers produced large mass and lipid outputs with a large lipid fraction deposited in the lower stage of a two-stage impinger. The Liberty (Ultrasonic) nebuliser failed to deliver more than 6% of the lipid employed.Multilamellar liposomes were generated from ethanol-based proliposomes. The resultant vesicles entrapped 62% of the available salbutamol sulphate compared to only 1.23% entrapped by liposomes made by the thin film method. Aeroneb Pro or Aeroneb Go vibrating-mesh nebulisers generated aerosol droplets of larger volume median diameter and narrower size distribution than the Pari (air-jet) nebuliser. Unlike the vibrating-mesh nebulisers, the performance of the jet nebuliser was independent of formulation. A nebuliser-dependent significant loss of the originally entrapped drug was demonstrated. A customised large mesh Aeroneb Pro reduced the drug losses during nebulisation.

O autorze

Dr A Elhissi & Prof W Ahmed (University of Central Lancashire) are involved the study of nanoparticles and nanomaterials in medical and engineering applications. Prof K Taylor (University of London) is researching liposomal systems for drug delivery involving formulation, manufacture and evaluation of their potential for controlled drug delivery.