Nano-Biotechnology for Biomedical and Diagnostic Research

ISBN-13: 9789401779074 / Angielski / Miękka / 2016 / 182 str.

Eran Zahavy; Arie Ordentlich; Shmuel Yitzhaki

Opis

This book explores current research on nanomaterials in imaging and biological research, nanomaterials as a biosensing tool, DNA nanotechnology, nanomaterials for drug delivery, medicinal and therapeutic application and cytotoxicity of nanomaterials.

Spis treści

Preface.- 1. Biomolecule/Nanomaterial Hybrid Systems for Nanobiotechnology.- 1.1. Electrical Contacting of Enzymes with Electrodes for the Construction of Amperometric Biosensors and Biofuel Cells.- 1.2. Catalytic Properties of Metalic Nanoparticles (NPs) and their Implementation for Sensing and Nanocircuitry.- 1.3. Bioanalytical Applications of Hybrid Semiconductor-Protein Systems.- 1.4. Biomolecules as Templates for Nanoscale Circuitry.- 1.5.  Conclusions and Perspectives.- 2. Superresolution Optical Flunctuation Imaging.- 2.1. Main article.- 2.2. Conclusion.- 3. Application of Nanoparticles for the Detection and Sorting of Pathogenic Bacteria by Flow-Cytometry.- 3.1. Introduction.- 3.2. Results.- 3.3.         Conclusion.- 4. Advancing Nanostructured Porous Si-Based Optical Transducers for Label Free Bacteria Detection.- 4.1. Introduction.- 4.2. Materials and Methods.- 4.3. Results and Discussion.- 4.4. Conclusions.- 5. Gold Fibers as a Platform for Biosensing.- 5.1. Introduction.- 5.2. Experimental.- 5.3. Results and Discussion.- 5.4. Electrochemical Evaluation of Gox on Gold Fibers.- 5.5. Summary and Conclusions.- 6. Surface-Enhanced Raman Spectroscopy of Organic Molecules Adsorbed on Metallic Nanoparticles.- 6.1. Introduction.- 6.2. Experimental.- 6.3. Results and Discussion.- 6.4. Summary and Conclusions.- 7. Quantum Dots and Fluorescent Protein FRET-based Biosensors.- 7.1. Introduction.- 7.2. Materials and Methods.- 7.3. Results.- 7.4. Discussion.- 8. Semiconductor Quantum Dots as FRET-Acceptors for Multiplexed Diagnostics and Molecular Ruler Application.- 8.1. Introduction.- 8.2. Short Theoretical and Practical Background.- 8.3. Applications.-

8.4. Conclusions and Outlook.- 9. Assembly and Microscopic Characterization of DNA Origami Structures.- 9.1. Introduction.- 9.2. DNA as a Material for ?Molecular Self-Assembly.- 9.3. Modification of Origami Structures.- 9.4. Characterization of DNA Origami Structures.- 9.5. Conclusion and Outlook.- 10. DNA Nanotechnology.- 10.1. DNA Nanostructures for Amplified Sensing.- 10.2. Ultrasensitive Detection of DNA through Isothermal Replication Processes using DNA Enzymes.- 10.3. Programmed Nanostructures Acting as DNA Machines.- 10.4. Self-Assembly of Functional DNA-Protein Nanostructures.- 10.5. Conclusions and Perspectives.- 11. Role of Carbohydrate (lectin) receptors in the Macrophage Uptake of Dextran-Coated Iron Oxide Nanoparticles.-  11.1. Introduction.- 11.2. Materials and Methods.- 11.3. Results and Discussion.- 11.4. Conclusions.- 12. Toxicity of Gold Nanoparticles on Somatic and Reproductive Cells.- 12.1. Introduction.-  12.2. Effect of Gold Nanoparticles on Somatic Cells.- 12.3. Reproductive Toxicology of Gold Nanoparticles.- 12.4. Conclusion.-13. Ultrasound Activated Nano-Encapsulated Targeted Drug Delivery and Tumour Cell Poration.- 13.1. Introduction.- 13.2. Materials and Methods.- 13.3. Results.- 13.4. Discussion.- 13.5. Future Work.- 14. Ultrasound Mediated Localized Drug Delivery.- 14.1. Introduction.- 14.2. Ultrasound Intensity Level of 1.5 MPa.- 14.3. Ultrasound Intensity Levels Below 1 MPa.- 14.4. Localized SHERPA Activation.- 14.5. Discussion.- 14.6. Conclusions.- 15. Sonochemical Proteinaceous Microspheres for Wound Healing.- 15.1. Introduction.- 15.2. Materials and Methods.- 15.3. Results and Discussion.- 15.4. Conclusions.- 16. Alendronate Liposomes for Antitumor Therapy: Activation of γδ T Cells and Inhibition of Tumor Growth.- 16.1. Introduction.- 16.2. Materials and Methods.- 16.3. Results.- 16.4. Discussion.

Blurb

The title "Nano Biotechnology for Biomedical and Diagnostics Research" will address research aspects related to nanomaterial in imaging and biological research, nanomaterials as a biosensing tool, DNA nanotechnology, nanomaterials for drug delivery, medicinal and therapeutic application and cytotoxicity of nanomaterials. These topics will be covered by 16 different manuscripts. Amongst the authors that will contribute to the book are major scientific leaders such as S. Weiss - UCLA, I. Willner, and G. Golomb – HUJI, S. Esener - UCSD, E.C. Simmel - Tech. Univ. Munchen, I. Medintz – NRL, N. Hildebrandt - Université Paris and more. The manuscripts in the book intend to present specifically biological, diagnostics and medical problems with their potential solution by nano technology or materials. In this respect this book is unique, since it would arise from the biological problems to the nano technology possible solution and not vice versa.