Nano-Biomaterials for Ophthalmic Drug Delivery

ISBN-13: 9783319805481 / Angielski / Miękka / 2018 / 627 str.

Yashwant Pathak; Vijaykumar Sutariya; Anjali A. Hirani

Spis treści

Forward.- Preface.- Introduction.- Overview of the Ophthalmic System.- Pharmacological Considerations in Ophthalmic Drug Delivery.- Pathophysiology of Vision.- Nanotechnology and Nanomaterials in Ophthalmic Drug Delivery.- Pharmacokinetics and Pharmacodynamics of Ocular Drugs.- Physicochemical Requirements for Polymers and Polymer Based Nanomaterial for Ophthalmic Drug Delivery.- Formulation Approaches for Ocular Drug Delivery.- Ocular Permeation Enhancers.- Ocular Bioadhesives and their Applications in Ophthalmic Drug Delivery.- Nano Vesicular Carrier Systems for Ophthalmic Drug Delivery.- Cyclodextrins in Ocular Drug Delivery.- Ocular Preservatives: Risks and Recent Trends in its Application in Ocular Drug Delivery (ODD).- Ageing Disorders of The Eye: Challenges and Approaches for their Treatment.- Colloidal Carriers in Ophthalmic Drug Delivery.- Polymeric Nanoparticulate Systems: A potential Approach for Occular Drug Delivery.- Barriers to Glaucoma Drug Delivery and Resolving the Challenges Using Nanotechnology.- Intraocular Drug Delivery Technologies: Advancing Treatment of Posterior Segment Disorders of the Eye.- Animal Models to Evaluate Nanoparticulate Ocular Drug Delivery Systems.- Ophthalmic Nanosuspensions: Toxicity and Formulation.- Ocular Drug Delivery: Impact of In Vitro Cell Culture Models.- Nanotoxicity of Nanobiomaterials in Ocular Systems and its Evaluation.- Nanosystem in Ocular Bioenvironment.- Excipients Utilized for Ophthalmic Drug Delivery Systems.- Ophthalmic Drug Delivery Systems for Treatment of Corneal Diseases.- Challenges in Ocular Pharmacokinetics and Drug Delivery.

O autorze

Yashwant Pathak, M.Pharm., EMBA, MS (Conflict Management), Ph.D.

Dr. Yashwant Pathak completed his M.S. and Ph.D. in Pharmaceutical Technology from Nagpur University, India and EMBA and MS in Conflict Management from Sullivan University, Louisville, KY. He is the Associate Dean for Faculty Affairs at College of Pharmacy, University of South Florida in Tampa, FL. With extensive experience in academia as well as industry, he has more than 100 publications, 2 patents applications, 5 books in Nanotechnology and 4 in Nutraceuticals and several books in cultural studies. His areas of research include drug delivery systems and its characterization in animal models.

Vijaykumar Sutariya, B.Pharm., M.Pharm., Ph.D.

Dr. Vijaykumar Sutariya received his Bachelors and Masters in Pharmacy from L. M. College of Pharmacy, Gujarat University, Ahmedabad, India and Ph.D. in Pharmacy from The M.S. University of Baroda, Vadodara, India. He did his postdoctoral training in pharmaceutics and drug delivery at Butler University, Indianapolis, IN. Dr. Sutariya is an Assistant Professor in the Department of Pharmaceutical Sciences at the USF College of Pharmacy. He has a joint appointment with the Department of Internal Medicine, Division of Translational Medicine at USF. Dr. Sutariya’s research is focused on development of novel drug delivery systems such as nanoparticles, liposomes and thermoreversible gels. 

Anjali Hirani, Ph.D.

Dr. Anjali Hirani received her M.S. and Ph.D. in Biomedical Engineering from Virginia Tech, Blacksburg, VA. She is currently a postdoctoral fellow at the University of South Florida in the College of Pharmacy. Her research is focused on the development of sustained drug delivery systems for ocular disease. 

Blurb

This consolidated reference book addresses the various aspects of nano biomaterials used in ophthalmic drug delivery, including their characterization, interactions with ophthalmic system and applications in treatments of the ophthalmic diseases and disorders. In the last decade, a significant growth in polymer sciences, nanotechnology and biotechnology has resulted in the development of new nano- and bioengineered nano-bio-materials. These are extensively explored as drug delivery carriers as well as for implantable devices and scaffolds. At the interface between nanomaterials and biological systems, the organic and synthetic worlds merge into a new science concerned with the safe use of nanotechnology and nano­ material design for biological applications. For this field to evolve, there is a need to understand the dynamic forces and molecular components that shape these interactions. While it is impossible to describe with certainty all the bio­ physicochemical interactions at play at the interface, we are at a point where the pockets of assembled knowledge are providing a conceptual framework to guide this exploration, and review the impact on future product development. The book is intended as a valuable resource for academics and pharmaceutical scientists working in the field of polymers, polymers materials for drug delivery, drug delivery systems and ophthalmic drug delivery systems, in addition to medical and health care professionals in these areas.