NSAIDS and Aspirin: Recent Advances and Implications for Clinical Management

ISBN-13: 9783319816258 / Angielski / Miękka / 2018 / 263 str.

Lanas, Angel

Opis

This volume is a state-of-the art resource on the recent advances and clinical management of NSAIDs and aspirin. The text provides a thorough overview of NSAIDS and aspirin, reviewing such topics as pharmacology and mechanisms, clinical effects, and the safety and efficacy of these drugs. It also focuses on the effect of the drugs on the cardiovascular system and in the prevention of GI cancer. Practical recommendations for a safe prescription of NSAIDs are also included. Written by experts in the field, NSAIDs and Aspirin: Recent Advances and Implications for Clinical Management is a comprehensive text of great value to gastroenterologists, rheumatologists, cardiologists, oncologists, orthopedists, trauma and internal medicine specialists.

Recenzje

"This well-organized book describes the pharmacology and effects on various organ systems of aspirin and NSAIDS, and guides clinical decision making regarding the use of these medications. ... It is appropriate specifically for medical students interested in gastroenterology, but it can be used by those interested in other fields of medicine to better understand the significance of NSAIDs and aspirin. The author is very well versed in this area." (Noah Settergren, Doody's Book Reviews, March, 2017)

Spis treści

Section 1. Pharmacology and Mechanisms

Chapter 1. Chemistry, Pharmacodynamics, and Pharmacokinetics of NSAIDs

Sara Calatayud and Juan Vicente Esplugues

Chapter 2. Principles, Mechanisms of Action, and Future Prospects of Anti-Inflammatory Drugs

Bibiana Rius and Joan Clària 

Section 2. Clinical Effects and Drug Safety

Chapter 3. Efficacy of NSAIDs in the Treatment of Rheumatic Diseases

Marc C. Hochberg and Lee S. Simon

Chapter 4.  Adverse Effects of NSAIDs in the Gastrointestinal Tract: Risk Factors of Gastrointestinal Toxicity with NSAIDs

Sunny H. Wong and Francis K.L. Chan

Chapter 5. Adverse Effects of NSAIDs on the Cardiovascular System

Carmelo Scarpignato and Corrado Blandizzi

Chapter 6.  Safe Prescription of NSAIDs in Clinical Practice

Mohammad Yaghoobi and Richard H. Hunt

Section 3. Aspirin

Chapter 7. NSAIDS and Aspirin: Recent Advances and Implications for Clinical Management

Karsten Schrör and Michael Voelker

Chapter 8. Non-Prescription Analgesic Anti-inflammatory Drugs: Efficacy and Safety

Denis M. McCarthy

Chapter 9. Low-Dose Aspirin in the Cardiovascular System

Ruben Casado-Arroyo, Angel Lanas, and Pedro Brugada

Chapter 10. Adverse Effects of Low-Dose Aspirin in the Gastrointestinal Tract

Katsunori Iijima

Chapter 11. Aspirin in the Treatment and Prevention of Cardiovascular Disease: Need for Individual Clinical Judgments

Angel Lanas and Charles H. Hennekens

Section 4. NSAIDS and Aspirin in Cancer Prevention

Chapter 12. Molecular and Experimental Basis for COX-Inhibition in Cancer

Annalisa Bruno, Melania Dovizio, and Paola Patrignani

Chapter 13. Clinical Effects of NSAIDs and Coxibs in Colon Cancer Prevention

Elena Piazuelo and Angel Lanas

Chapter 14. Aspirin and the Prevention of Colorectal Cancer 

Paul J. Lochhead and Andrew T. Chan

Chapter 15. A Rational Approach for the Use of NSAIDs and/or Aspirin in Cancer Prevention in the Near Future: “Balancing Risk and Benefits”

Elizabeth Half, Ahmad Fokra, and Nadir Arber 

O autorze

Prof. Angel Lanas graduated in medicine from the University of Zaragoza, in Zaragoza, Spain, in 1979. He completed postgraduate training in internal medicine at Zaragoza’s University Hospital and was awarded his doctor of medicine degree from the University of Zaragoza in 1984. Prof. Lanas took a position as a research fellow at the same university before working as a gastroenterologist staff member at various Spanish hospitals between 1986 and 1999. From 1989 to 1991, Prof. Lanas also joined the Department of Gastroenterology at the University of Alabama at Birmingham, in Birmingham, Alabama, as a visiting professor. He returned to Spain in 1992 as an associate professor of medicine at the University of Zaragoza. In 1999 he became clinical chief of gastroenterology at the University Hospital and in 2006 professor of medicine at the University of Zaragoza.

 

Since 1987, Prof. Lanas has been the recipient of multiple research grants from various Spanish funding bodies. He has also received grants from private foundations and companies for research mainly focused on the adverse effects of various drugs, especially nonsteroidal anti-inflammatory drugs, on the gastrointestinal tract. He is affiliated with multiple national and international gastroenterological associations and is or has been a member of different executive committees for various international studies. 

Since 2000, he has published more than 80 research and review publications in the field of gastroenterology. Prof. Lanas’ research interests include acid-, H. pylori- and NSAID-related gastrointestinal diseases. Chemoprevention of GI cancer