NMR Spectroscopy of Biological Solids

ISBN-13: 9780367392086 / Angielski / Miękka / 2019 / 368 str.

A. Ramamoorthy

Opis

Filling a void in the current literature, NMR Spectroscopy of Biological Solids examines all the recent developments, implementation, and interpretation of solid-state NMR experiments and the advantages of applying them to biological systems. Authored by world-renowned experts, the book emphasizes how these techniques can be used to realize the structure of non-crystalline systems of any size. Addressing principles, methods, and applications, this book provides a critical selection of solid-state NMR methods for solving a wide range of practical problems that arise in both academic and industrial research of biomolecules in the solid state.

Spis treści

Introduction to Solid-State NMR Spectroscopy. Analysis of Pulse Sequences Using Computer Simulations. Measurement of NMR Parameters from Aligned Biological Solids. Variation of Chemical Shift Tensors in Proteins. Assignment of Resonances from Uniformly Labeled Proteins. Methods to Measure Interatomic Distances. Multidimensional Experiments to Study Solids Under Magic Angle Spinning. Fluorine-19 NMR to Enhance the Sensitivity. Proton-Detected Solid-State NMR Experiments. Structure, Dynamics, and Mechanism of Membrane-Disruptive Peptides. Topology of Membrane-Associated Proteins. Spin Interaction Tensors and Protein Dynamics in Model Membranes. Structure of Crystalline Proteins. Structure and Assembly of Amyloid Fibrils. Structure of Ligands Bound to Receptor Proteins. Structure and Mechanism of Fusion Peptides. Investigation of Metal-Bounds Proteins.

O autorze

A. Ramamoorthy