Myocardial Ischemia and Arrhythmia: Under the Auspices of the Society of Cooperation in Medicine and Science (Scms), Freiburg, Germany

ISBN-13: 9783642725074 / Angielski / Miękka / 2011 / 301 str.

M. Zehender; T. Meinertz; H. Just

Opis

This volume presents, in synoptic form, the latest and most comprehensive experimental and multi-faceted clinical findings on the potential arrythmogenic implications of acute myocardial ischemia. Together with a critical discussion of the related diagnostic and therapeutic consequences and outcomes, it presents a solid basis for efforts to reduce the occurance of sudden cardiac death in patients with coronary heart disease.

Spis treści

Metabolic aspects and channel kinetics in cellular hypoxia.- Calcium homeostasis, myocardial ischemia and arrhythmogenic impact.- Selected metabolic alterations in the ischemic heart and their contributions to arrhythmogenesis.- Arrhythmogenic effects of selective inhibition of cyclic nucleotide phosphodiesterase isoenzymes in pig myocardium.- Ischemia and early extracellular K+ accumulation in cardiac cells.- Characteristics of transport processes involved in ischemia and reperfusion.- Ionic and metabolic progenitors of reperfusion arrhythmias.- Electrophysiologic properties of cellular hypoxia and myocardial ischemia.- Anisotropy and anisotropic reentry in myocardial infarction.- Effects of the sympathetic nervous system on conduction and refractoriness in normal and ischemic myocardium.- Sympatho-adrenergic activation of the ischemic myocardium and its arrhythmogenic impact.- Factors determining the arrhythmogenic potency of myocardial ischemia and time-course of ischemia related arrhythmias.- Pathophysiology of acute ischemia: Potential targets for Antiarrhythmic drugs.- Acute and chronic myocardial ischemia in the arrhythmogenesis and aggravation of ventricular arrhythmias.- Risk stratification and prediction of sudden death following myocardial infarction.- Ventricular tachyarrhythmias, myocardial ischemia and sudden cardiac death in patients with hypertensive heart disease.- Vascular mechanisms leading to myocardial ischemia and their relation to hypertension, left ventricular hypertrophy and arrhythmias.- Clinical evidence for the fatal interaction of ventricular tachyarrhythmias, myocardial ischemia and sudden cardiac death.- Autonomic nervous system, myocardial ischemia, and malignant ventricular arrhythmias: Experimental findings.- Assessment of autonomic tonus and reflexes in patients after myocardial infarction.- Clinical aspects in the treatment of ischemia-related ventricular arrhythmias.- Coronary artery bypass graft surgery for the prevention of sudden cardiac death.- Myocardial ischemia, ventricular arrhythmias and implantable cardioverter-defibrillators: Importance of stored electrograms.- Therapeutic consequences of newer studies addressing the problem of myocardial ischemia and ventricular arrhythmias.