Myocardial Energy Metabolism

ISBN-13: 9789401070874 / Angielski / Miękka / 2011 / 310 str.

J. W. Jong

Spis treści

List of Contributors.- Basic Mechanisms.- 1. ATP-metabolism in normoxic and ischemic heart..- 2. Development of myocardial energy metabolism..- 3. Principles of fuel metabolism in heart muscle..- 4. Carnitine and cardiac energy supply..- 5. Adenine nucleotides, purine metabolism and myocardial function..- 6. On the role of myocardial AMP-deaminase..- 7. Redox manipulation of free cardiac adenylates and purine nucleoside release..- 8. Regulation of myocardial perfusion by purine metabolites..- 9. Cardiac electrophysiological effects of adenosine..- 10. Acceleration of adenine nucleotide biosynthesis after ischemic insult..- Technical Considerations/Models.- 11. The importance of the determination of ATP and catabolites..- 12. Cardiac energy metabolism probed with nuclear magnetic resonance..- 13. Positron emission tomography and myocardial biochemistry..- 14. Energy metabolism and transport in neonatal heart cells in culture..- 15. Energy metabolism of adult cardiomyocytes..- 16. Ischemia, high-energy phosphate metabolism and sarcomere dynamics in myocardium..- 17. Myocardial function and metabolism during ischemia and reperfusion in anesthetized pigs..- 18. The energetics of “stunned” myocardium..- 19. Energy depletion due to the calcium paradox..- Clinical Implications.- 20. Human purine metabolism..- 21. Diagnosis of ischemic heart disease with AMP-catabolites..- 22. Myocardial high-energy phosphates during open-heart surgery..- 23. Apparent inosine incorporation and concomitant haemodynamic improvement in human heart..- 24. Cardioplegia and calcium entry blockade..- 25. The effect of anesthetics on myocardial adenine nucleotides..- 26. Regeneration of adenine nucleotides in the heart..