Myeloproliferative Neoplasms: Biology and Therapy

ISBN-13: 9781607612650 / Angielski / Twarda / 2010 / 230 str.

Srdan Verstovsek; Ayalew Tefferi

Opis

This succinct resource provides an ideal balance of the biology and practical therapeutic strategies for classic and non-classic BCR-ABL-negative myeloproliferative neoplasms. Utilizing current World Health Organization nomenclature, classification, and diagnostic criteria, international experts have assembled to convey the most up-to-date knowledge in this rapidly evolving field. The opening chapters cover the diagnosis and classification, genetics, cytogenetic findings, and prognostic factors of MPNs. Further chapters explore therapies specific to the different disease entities, including polycythemia vera, essential thrombocytopenia, myelofibrosis, and eosinophilic disorders, and mastocytosis. Unique areas of discussion include JAK2 inhibitor therapy, hematopoietic stem cell transplantation, and blastic transformation. A valuable reference for practicing hematologists, this forefront book enriches our understanding of recent discoveries and their impact on conventional and investigational treatments.

Spis treści

Chapter 1 - Diagnosis and Classification of the BCR-ABL-negative Myeloproliferative Neoplasms James W. Vardiman and Carlos E. Bueso-Ramos Chapter 2 - Genetics of the Myeloproliferative Neoplasms Omar Abdel-Wahab and Ross L. Levine Chapter 3 - Cytogenetic Findings in Classic Myeloproliferative Neoplasms John T Reilly Chapter 4 - Prognostic Factors in Classic Myeloproliferative Neoplasms Francisco Cervantes and Juan-Carlos Hernández-Boluda Chapter 5 - Therapy of Polycythemia Vera and Essential Thrombocythemia Guido Finazzi and Tiziano Barbui Chapter 6 - Conventional and Investigational Therapy for Primary Myelofibrosis Giovanni Barosi Chapter 7 - Hematopoietic Cell Transplantation for Myelofibrosis Daniella M.B. Kerbauy and H.Joachim Deeg Chapter 8 - JAK2 Inhibitors as Therapy for Classic Myeloproliferative Neoplasms Fabio P S Santos and Srdan Verstovsek Chapter 9 - Blastic Transformation of Classic Myeloproliferative Neoplasms Ruben A. Mesa Chapter 10 - Eosinophilic Disorders: Differential Diagnosis and Management Jason Gotlib Chapter 11 - Pathogenesis, Diagnosis, Classification, and Management of Systemic Mastocytosis Animesh Pardanani and Ayalew Tefferi