Contributors
Preface
Acknowledgments
About the Editor
Section I Introduction and History
1 Paul Ehrlich and the Early History of Granulocytes
A. Barry Kay
2 The Phagocyte, Metchnikoff, and the Foundation of Immunology
Giuseppe Teti, Carmelo Biondo, and Concetta Beninati
3 Growth and Differentiation Factors
Donald Metcalf and Nicos A. Nicola
Section II General Aspects
4 Evolution of Myeloid Cells
Daniel R. Barreda, Harold R. Neely, and Martin F. Flajnik
5 Advances on Myeloid Like-Cell Origins and Functions in the Model Organism Drosophila melanogaster
Laure El Chamy, Nicolas Matt, and Jean-Marc Reichhart
6 Monocyte, Macrophage, and Dendritic Cell Development: the Human Perspective
Matthew Collin and Venetia Bigley
7 Myeloid Cell Turnover and Clearance
William J. Janssen, Donna L. Bratton, Claudia V. Jakubzick, and Peter M. Henson
Section III Specialization
8 Transcriptional Regulation and Macrophage Differentiation
David A. Hume, Kim M. Summers, and Michael Rehli
9 Murine Monocytes: Origins, Subsets, Fates, and Functions
Alexander Mildner, Goran Marinkovic, and Steffen Jung
10 Dendritic Cells in the Immune System--History, Lineages, Tissues, Tolerance, and Immunity
Jonathan M. Austyn
11 Antigen Processing and Presentation Mechanisms in Myeloid Cells
Paul A. Roche and Peter Cresswell
12 Microglia
V. Hugh Perry
13 Osteoclasts--Key Players in Skeletal Health and Disease
Deborah Veis Novack and Gabriel Mbalaviele
14 The Regulatory Function of Eosinophils
Ting Wen and Marc E. Rothenberg
Section IV Recruitment, Inflammation, and Repair
15 Intravital Imaging of Myeloid Cells: Inflammatory Migration and Resident Patrolling
Justin F. Deniset and Paul Kubes
16 Multifaceted Functions of NOD-Like Receptor Proteins in Myeloid Cells at the Intersection of Innate and Adaptive Immunity
Thomas A. Kufer, Giulia Nigro, and Philippe J. Sansonetti
17 Inflammasomes in Myeloid Cells: Warriors Within
Sushmita Jha and Jenny Pan-Yun Ting
18 Inflammation--a Critical Appreciation of the Role of Myeloid Cells
Asif J. Iqbal, Edward A. Fisher, and David R. Greaves
19 Lipid Mediators in Inflammation
Melanie Bennett and Derek W. Gilroy
20 Macrophage Proresolving Mediators--the When and Where
Jesmond Dalli and Charles Serhan
21 Myeloid Cells in Cutaneous Wound Repair
Jenna L. Cash and Paul Martin
Section V Recognition, Signaling, and Gene Expression
22 The Role and Function of Fcgamma Receptors on Myeloid Cells
Stylianos Bournazos, Taia T. Wang, and Jeffrey V. Ravetch
23 Complement Receptors in Myeloid Cell Adhesion and Phagocytosis
Michael L. Dustin
24 Toll-Like Receptor Signaling and Its Inducible Proteins
Takashi Satoh and Shizuo Akira
25 Lectin Receptors Expressed on Myeloid Cells
Gordon D. Brown and Paul R. Crocker
26 G Protein-Coupled Receptors in Macrophages
Hsi-Hsien Lin and Martin Stacey
27 Molecular Mechanisms of Phagosome Formation
Valentin Jaumouillé and Sergio Grinstein
28 Role of the Cytoskeleton in Myeloid Cell Function
Noah Fine, Samira Khaliq, Siavash Hassanpour, and Michael Glogauer
29 Coordinated Regulation of Signaling Pathways during Macrophage Activation
Toby Lawrence
30 Genome-Wide Approaches to Defining Macrophage Identity and Function
Gregory J. Fonseca, Jason S. Seidman, and Christopher K. Glass
31 Epigenetic Regulation of Myeloid Cells
Lionel B. Ivashkiv and Sung Ho Park
Section VI Secretion and Defense
32 Secretion from Myeloid Cells: Secretory Lysosomes
Gillian M. Griffiths
33 The NADPH Oxidase and Microbial Killing by Neutrophils, With a Particular Emphasis on the Proposed Antimicrobial Role of Myeloperoxidase within the Phagocytic Vacuole
Adam P. Levine and Anthony W. Segal
34 Evolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune Cells
Ryan G. Gaudet, Clinton J. Bradfield, and John D. MacMicking
35 Anti-TNF Therapy
Irina Udalova, Claudia Monaco, Jagdeep Nanchahal, and Marc Feldmann
36 Metalloproteinases: a Functional Pathway for Myeloid Cells
Jonathan Chou, Matilda F. Chan, and Zena Werb
Section VII Immunoregulation and Infection
37 Interplay between Myeloid Cells and Humoral Innate Immunity
Sébastien Jaillon, Eduardo Bonavita, Cecilia Garlanda, and Alberto Mantovani
38 Adaptive Characteristics of Innate Immune Responses in Macrophages
Rob J. W. Arts and Mihai G. Netea
39 Intestinal Mononuclear Phagocytes in Health and Disease
Theodore J. Sanders, Ulf Yrlid, and Kevin J. Maloy
40 Strategies Used by Bacteria to Grow in Macrophages
Gabriel Mitchell, Chen Chen, and Daniel A. Portnoy
41 Mechanisms of Defense against Intracellular Pathogens Mediated by Human Macrophages
Barry R. Bloom and Robert L. Modlin
42 Myeloid Cells in Asthma
Bart N. Lambrecht, Emma Persson, and Hamida Hammad
43 Myeloid Cell Phenotypes in Susceptibility and Resistance to Helminth Parasite Infections
Rick M. Maizels and James P. Hewitson
44 Induction of Immunological Tolerance as a Therapeutic Procedure
Herman Waldmann, Duncan Howie, and Stephen Cobbold
Section VIII Metabolic and Malignant Disease
45 Glutathione and Glutathione Transferase Omega 1 as Key Post-Translational Regulators in Macrophages
Mark M. Hughes, Anne F. McGettrick, and Luke A.J. O'Neill
46 Macrophages and Iron Metabolism
Tomas Ganz
47 Mechanisms of Myeloid Cell Modulation of Atherosclerosis
Filip K. Swirski, Matthias Nahrendorf, and Peter Libby
48 Macrophages in Endocrine Glands with Emphasis on Pancreatic Islets
Emil R. Unanue
59 Tumor-Induced Myeloid-Derived Suppressor Cells
Francesco De Sanctis, Vincenzo Bronte, and Stefano Ugel
50 Myeloid Cell Origins, Differentiation, and Clinical Implications
Kipp Weiskopf, Peter J. Schnorr, Wendy W. Pang, Mark P. Chao, Akanksha Chhabra, Jun Seita, Mingye Feng, and Irving L. Weissman
Index