Mutation Research: Problems, Results and Perspectives

ISBN-13: 9780412112805 / Angielski / Miękka / 1976 / 504 str.

Charlotte Auerbach

Opis

This book is intended for the senior undergraduate (Honours student) in genetics, and for the postgraduate who wants a survey of the whole field or information on a special area within it. In addition to the references at the end of each chapter, a bibliography at the end of the book lists relevant books and general reviews.

Spis treści

1 The history of mutation research.- 2 Classification of mutational changes at the chromosomal level.- 3 Classification of gene mutations.- 4 Reverse mutations. Suppressors.- 5 The classical X-ray work. I: Mutations. The target theory.- 6 The classical X-ray work II: Chromosome breaks and rearrangements. Do X-rays produce true gene mutations?.- 7 Direct and indirect action of X-rays. Radio-isotopes. Radiation-sterilized food.- 8 Repair of X-ray damage I: Repair of chromosome breaks.- 9 Repair of X-ray damage II: Repair of mutagenic lesions. Molecular action of X-rays. Sensitivity differences.- 10 Mutagenesis by ultraviolet and visible light I: Early work on macro-organisms.- 11 Mutagenesis by ultraviolet and visible light II: Methods of mutation research on microorganisms and mammalian cell cultures.- 12 Mutagenesis by ultraviolet and visible light II: Early work on micro-organisms.- 13 The molecular action of ultraviolet and visible light I: Photoproducts. Photorepair.- 14 The molecular action of ultraviolet and visible light II: Dark repair. Mechanisms of mutation induction.- 15 Chemical mutagens: alkylating agents. I: Genetical effects.- 16 Chemical mutagens: alkylating agents. II: Chemistry. Molecular analysis of mutants. Influence of cellular processes. Kinetics.- 17 Chemical mutagens: purines; base analogues; acridines; hydroxylamine; hydrazine; bisulphite. Reversions analysis.- 18 Nitrous acid. Other chemical mutagens.- 19 The relation between induced crossovers, rearrangements and mutations. The origin of complete (non-mosaic) mutations.- 20 Mutagen specificity.- 21 Spontaneous mutations.- 22 Instabilities.- 23 Applied mutation research.- Author Index.