Mutagenesis of the Mouse Genome

ISBN-13: 9781402028755 / Angielski / Twarda / 2005 / 98 str.

Monica Justice; Mary Bedell

Opis

The Second Georgia Genetics Symposium was held color. Soon after, he joined the sta? of The Jackson in September 2000, and the development of this Laboratory in Bar Harbor, Maine. book took place over the nearly 4 years that ensued. Much of Bill's research at the lab was centered During this time, many advances in the Genome around investigating phenotypic variability within Project and mouse mutagenesis were made. In the highly inbred strains, and in that connection he book overview, we discuss the development of the developed the technique of ovarian transplanta- Genome Project (which is the context for the sym- tion (even using embryonic donors) and a genetic posium), the role the mouse was playing at that scheme whereby graft compatibility could be time, how that role has evolved, and how the combined with the ability to distinguish o?spring chapters of the book address issues in mouse func- from donor and regenerated host ovaries. His tional genetics. Many of the chapters in this book work was in?uenced by the second World War, will provide useful resources for years to come. ?rst because The Jackson Laboratory turned into Of greater impact, our keynote speaker, the a production colony for the military, primarily to mutagenesis pioneer William L. (Bill) Russell, produce mice for typhoid testing, and secondly, passed away on July 23, 2003.

Recenzje

From the reviews:

"Mutagenesis of the Mouse Genome is a collection of papers originally presented at the Second Georgia Genetics Symposium in 2002 and printed in a special issue of Genetica in 2004. ... this volume collects in one place much information that will prove valuable to current and prospective users of the wealth of mice produced by chemical mutagenesis. ... this book provides a strong introduction to the origins, acquisition and use of mutagenized mice." (Elissa J. Chesler, Genes, Brain and Behaviour, Vol. 5, 2006)

Spis treści

Foreword; M. Justice From the Atomic Age to the Genome Project; M.J. Justice Chemical mutagenesis of the mouse genome: an overview; J.-L. Guénet Effects of male germ-cell stage on the frequency, nature, and spectrum of induced specific-locus mutations in the mouse; L.B. Russell Allelic mutations of the sodium channel SCN8A reveal multiple cellular and physiological functions; M.H. Meisler, N.W. Plummer, D.L, Burgess, D.A. Buchner, L.K. Sprunger Towards a mutant map of the mouse – new models of neurological, behavioural, deafness, bone, renal and blood disorders; S. Rastan, T. Hough, A. Kierman, A. Erven, I.C. Gray, S. Voeling, A. Isaacs, H. Tsai, M. Strivens, R. Washbourne, C. Thornton, S. Greenaway, M. Hewitt, S. McCormick, R. Selley, C. Wells, Z. Tymowska-Lalanne, P. Roby, P. Mburu, D. Rogers, D. Kelsell, J.-L. Guénet, K.P. Steel, S. Sheardown, N. Spurr, I. Gray, J. Peters, P.M. Nolan, A.J. Hunter, S.D.M. Brown Implementing large-scale ENU mutagenesis screens in North America; A.T. Clark, D. Goldowitz, J.S. Takashi, M.H., Viterna, S.M. Siepka, L.L. Peters, W.N. Frankel, G.A. Carlson, J. Rossant, J.H. Nadeau, M.J. Justice Genetic mapping and ENU mutagenesis; D.R. Beier, B.J. Herron The Mouse Phenome Project; M.A. Bogue, S.C. Grubb Genetically altered mice: phenotypes, no phenotypes, and Faux phenotypes; S.W. Barthold Visualizing the laboratory mouse: capturing phenotype information; M. Strivens, J.T. Eppig

Blurb

The Human Genome Project has changed our approach to biology. Sequence data are being acquired from multiple organisms at a phenomenal pace and mutagenesis is being carried out in many model organisms to discover gene functions. The mouse is the first mammal to be subjected to large-scale mutagenesis, for its biological similarities to the human will permit key discoveries. Mutagenesis of the Mouse Genome focuses on articles relevant to mouse chemical mutagenesis, and is dedicated to the memory of the mutagenesis pioneer, William L. Russell. Monica Justice provides an overview of the history of the Human Genome Project and use of the mouse as the primary organism for the functional annotation of the mammalian genome. With special articles by Jean-Louis Guenet describing the history and development of mouse chemical mutagenesis, Liane Russell analyzing decades of data on DNA damage after chemical treatment, Steven Barthold describing how environment can affect mouse phenotypes, Miriam Meisler summarizing the power of allelic series, Molly Bogue describing the variation in mouse inbred strains, and Mark Strivens and Janan Eppig showing how informatics tools can aid in functional analysis, this book is designed to be a handbook and reference guide for mouse genetics in the post-genome era.