Mutagenesis in Sub-Mammalian Systems: Status and Significance

ISBN-13: 9789401166416 / Angielski / Miękka / 2012 / 231 str.

G. E. Paget

Opis

Topics in Toxicology Toxicology is a science that stands at the intersection of several interests and disciplines. These intersecting forces are by no means all scientific since some are legal and some are commercial. All have valid things to say about the conduct and interpretation of toxicity experiments. The practising toxicologist must bear all these sometimes conflicting forces in mind as he carries out his duties. This is especially true, of course, of the toxicologist in industry. Toxicology is also a field in which contract research particularly flourishes and a number of major contract research companies have established over the years a reputation for contributing usefully to the practice of this skill. These contract research organisations are particu- larly favoured to develop an appreciation of the problems of the industrial toxicologist, since it is very common for such a company to service the toxicological needs of companies in several sectors of industry producing new chemical compounds, and the contract research company, therefore, is aware of a wider diversity of problems than probably affects a single toxicologist in one industry.

Spis treści

Section One General Background to Mutagenesis Studies.- 1 Mutagenesis — the significance of DNA damage for man.- 2 The role of Drosophila in mutagen testing.- Discussion.- Section Two Bacterial Tests for Mutagenesis.- 3 A strategy to minimize human exposure to environmental chemicals causing cancer and genetic birth defects.- 4 Practical experience in testing unknowns in vitro.- 5 Induced mutation in micro-organisms: validity for estimating risk to man.- Discussion.- Section Three Other Mutagenesis Test Systems.- 6 Sub-mammalian tests other than the Ames test for mutagenesis.- 7 Cytogenetic aspects of mutagenicity testing.- 8 Cell transformation assays.- 9 Implications of carcinogenicity.- Discussion.- Section Four General Implications of Mutagenesis.- 10 Extrapolation of mutagenic test results to man.- 11 Tests for mutagenesis from a regulatory point of view.- Discussion.- Round Table Discussion.- Concluding Remarks.