Muscarinic Receptors in Airways Diseases

ISBN-13: 9783034895323 / Angielski / Miękka / 2012 / 266 str.

Johan Zaagsma; Herman Meurs; Ad F. Roffel

Opis

What are the different muscarinic acetylcholine receptor subtypes and how are they distributed in the airways and molecular signalling mechanisms? What is their function in neurogenic and non-neurogenic control of the airways and in inflammatory mechanisms? How is their gene expression regulated? The great importance of muscarinic acetylcholine receptors for the pathophysiology and treatment of chronic inflammatory obstructive airways diseases calls for a comprehensive and integrated overview of the current knowledge to address such questions, to discuss the role of these receptor subtypes in diseases such as asthma and COPD, and to present novel perspectives on antimuscarinic drug development. The present book is the worthy result of this need. It points out innovative insights into the hitherto poorly understood role of postjunctional muscarinic M2 receptors in airway smooth muscle contraction and sheds some light on the novel concepts of antimuscarinic drug development, with special reference to the l

Spis treści

Cholinergic and noncholinergic parasympathetic control of airway smooth muscle.- Role of non-neuronal and neuronal acetylcholine in the airways.- Identification, localization and function of muscarinic receptor subtypes in the airways.- Functional roles of postjunctional muscarinic M2 receptors in airway smooth muscle.- Dysfunction of prejunctional muscarinic M2 receptors: role of environmental factors.- Muscarinic receptor-?-adrenoceptor cross-talk in airway smooth muscle.- Gene regulation of muscarinic receptor subtypes.- Muscarinic control of airway mucus secretion.- The role of anticholinergics in asthma and COPD.- Novel perspectives in anticholinergic therapy.