Multiple Sclerosis: Etiology, Diagnosis, and New Treatment Strategies

ISBN-13: 9781617373169 / Angielski / Miękka / 2010 / 246 str.

Michael J. Olek

Opis

A synthesis of current concepts about the evaluation, treatment, and future directions in MS. On the evaluation side, the authors review the use of MRI, magnetic resonance spectroscopy, functional MRI, and three-dimensional MRI, and consider the rapidly developing body of pathologic information they have yielded. On the treatment side, the focus is on recently approved medications (Novantrone), new indications for medications (CHAMPS Trial), medications in development (Oral Interferon Tau, Oral Copaxone, and Oral Cellcept), immunosuppressive therapy for both progressive disease and symptomatic therapy; the current medications for treating relapsing-remitting MS (Avonex, Betaseron, and Copaxone) are also discussed. For future directions, the authors present the current best thinking, as well as the latest discoveries in immunology relating to MS, including groundbreaking B-cell research and its applications to specific immunotherapies, and the use of immune markers for tracking the disease.

Recenzje

From the reviews:

"...offers a practical, management-oriented approach to MS and interpretation of current clinical literature. Unique to this publication is the review of pregnancy and cognitive issues." - Doody's Health Sciences Book Review Journal

"To provide current concepts, approaches to management, and future directions in multiple sclerosis research. ...This multiauthored text contains chapters covering clinical features, investigations, underlying mechanisms, and approaches to treatment of multiple sclerosis, with an attempt to outline future directions. ... The views and discussions in the book are fresh and up-to-date. ... Olek, summarizes the differential diagnosis, clinical features, and prognosis of multiple sclerosis and is the strongest and most important ... for general physicians." (Jock T. Murray, Annals of Internal Medicine, Vol. 142 (9), 2005)

"This multiauthor book consists of a series of 12 monographs on the various clinical aspects of multiple sclerosis and, as such, is aimed primarily at the general physician ... . it is a well-written text and neuroradiologists with a specific interest in multiple sclerosis will find the wealth of discussion on the current and future treatment strategies of the disease useful. ... This text might be more useful to junior medical staff starting research projects in the area of multiple sclerosis ... ." (Amlyn L. Evans and Daniel J. A. Connolly, Neuroradiology, Vol. 46, 2006)

Spis treści

Signs and Symptoms of Multiple Sclerosis Stanley van den Noort Differential Diagnosis, Clinical Features, and Prognosis of Multiple Sclerosis Michael J. Olek Role of Magnetic Resonance Imaging in the Diagnosis and Prognosis of Multiple Sclerosis Robert Zivadinov and Rohit Bakshi Cognitive Dysfunction in Multiple Sclerosis Darcy Cox and Laura Julian Multiple Sclerosis, Genetics, and Autoimmunity Michael Demetriou B-Cell Immunity in Multiple Sclerosis Yufen Qin and Pierre Duquette Multiple Sclerosis: A Case for Early Treatment Alex C. Tselis and Omar A. Khan Pregnancy and Multiple Sclerosis Christina Caon Treatment of Progressive Multiple Sclerosis Norman Wang Cyclophosphamide Therapy for Multiple Sclerosis Derek R. Smith Repair and Neuroprotective Strategies in Multiple Sclerosis Fernando Dangond Future Therapies Michael J. Olek Index

Blurb

The recent explosion of new information about the pathology, pathophysiology, clinical classification, imaging, and treatment of multiple sclerosis (MS) has dramatically opened the way to a deeper understanding of the disease and a more effective therapeutic landscape for patients. In Multiple Sclerosis: Etiology, Diagnosis, and New Treatment Strategies, leading MS physicians synthesize current concepts about the evaluation, treatment, and future directions in MS. On the evaluation side, the authors review the use of magnetic resonance imaging (MRI), magnetic resonance spectroscopy, functional MRI, and three-dimensional MRI, and consider the rapidly developing body of pathologic information they have yielded. On the treatment side, the focus is on recently approved medications (Novantrone), new indications for medications (CHAMPS Trial), medications in development (Oral Interferon Tau, Oral Copaxone, and Oral Cellcept), immunosuppressive therapy for both progressive disease and symptomatic therapy; the current medications for treating relapsing-remitting MS (Avonex, Betaseron, and Copaxone) are also discussed. For future directions, the authors present the current best thinking, as well as the latest discoveries in immunology relating to MS, including groundbreaking B-cell research, its applications to specific immunotherapies, and the use of immune markers for tracking the disease. Additional chapters cover the mechanism and application of myelin repair, bone marrow transplantation, combination therapy, and specific immunomodulatory treatments.
Comprehensive and up-to-date, Multiple Sclerosis: Etiology, Diagnosis, and New Treatment Strategies reviews all the current immunological, neuropsychological, imaging, and pregnancy issues associated with MS and shows how each is contributing to the still ongoing development of more efficacious therapies.